National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Diagnosis of Extrapulmonary tuberculosis (EPTB) remains cumbersome due to non-specific clinical presentation and paucibacillary nature of samples. Irreversible complications are common if not diagnosed and treated earlier. Successful treatment outcome of EPTB and control of emerging drug resistance depends on adherence to treatment based on drug susceptibility result. Objective of this research work was to study drug susceptibility pattern of M. tuberculosis isolates from EPTB specimen. Among 649 EPTB patients screened in a tertiary care teaching hospital for a period of over three years, 71 strains (10.9%) of M. tuberculosis complex (MTBC) were isolated and identified using conventional biochemical tests and MPT64Ag detection. Isolates were subjected to drug susceptibility testing in MGIT960 system to first line ATT drugs. Sensitivity to all drugs tested was observed in 71.83%, monoresistance in 25.35%, dual resistance to Streptomycin and Isoniazid in 2.81%. Monoresistance to PZA, Isoniazid, Streptomycin, Rifampicin and Ethambutol was observed in 9.9%, 5.6%, 4.2%, 2.8%, and 2.8% respectively. Monoresistance of, 18.3% from pus, 4.2% from pleural fluid and 1.4% each from ascitic fluid and urine respectively was encountered. None of the isolates belonged to MDR-TB. Our study reveals the absence of MDR from new extrapulmonary tuberculosis cases in this part of India.
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