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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 3557-3561
DOI: https://doi.org/10.20546/ijcmas.2017.610.419


Drug Susceptibility Pattern of Mycobacterium tuberculosis isolates from Extrapulmonary Tuberculosis Cases in Puducherry and Surrounding Tamil Nadu, South India
Gandhi Kandhakumari and Selvaraj Stephen*
Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, SBV University, Pillaiyarkuppam, Pondicherry - 607403, India
*Corresponding author
Abstract:

Diagnosis of Extrapulmonary tuberculosis (EPTB) remains cumbersome due to non-specific clinical presentation and paucibacillary nature of samples. Irreversible complications are common if not diagnosed and treated earlier. Successful treatment outcome of EPTB and control of emerging drug resistance depends on adherence to treatment based on drug susceptibility result. Objective of this research work was to study drug susceptibility pattern of M. tuberculosis isolates from EPTB specimen. Among 649 EPTB patients screened in a tertiary care teaching hospital for a period of over three years, 71 strains (10.9%) of M. tuberculosis complex (MTBC) were isolated and identified using conventional biochemical tests and MPT64Ag detection. Isolates were subjected to drug susceptibility testing in MGIT960 system to first line ATT drugs. Sensitivity to all drugs tested was observed in 71.83%, monoresistance in 25.35%, dual resistance to Streptomycin and Isoniazid in 2.81%. Monoresistance to PZA, Isoniazid, Streptomycin, Rifampicin and Ethambutol was observed in 9.9%, 5.6%, 4.2%, 2.8%, and 2.8% respectively. Monoresistance of, 18.3% from pus, 4.2% from pleural fluid and 1.4% each from ascitic fluid and urine respectively was encountered. None of the isolates belonged to MDR-TB. Our study reveals the absence of MDR from new extrapulmonary tuberculosis cases in this part of India.


Keywords: ATT drugs, Drug susceptibility testing, EPTB, M.tuberculosis.
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How to cite this article:

Gandhi Kandhakumari and Selvaraj Stephen. 2017. ‘Drug Susceptibility Pattern of Mycobacterium tuberculosis Isolates from Extrapulmonary Tuberculosis Cases in Puducherry and Surrounding Tamil Nadu, South India’.Int.J.Curr.Microbiol.App.Sci. 6(10): 3557-3561. doi: https://doi.org/10.20546/ijcmas.2017.610.419