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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 2782-2787
DOI: https://doi.org/10.20546/ijcmas.2017.610.326


An In Vitro Study of Effect of Water Soluble Vitamin B Complex on Antimicrobial Activity of Antibiotics against Klebsiella species Isolated from Respiratory Samples
Sowmya Nasimuddin*, Jeevan Malaiyan, Mohanakrishanan Kandaswamy, Swathithra Mohandass Nirmaladevi and Sumathi Gnanadesikan
Department of Microbiology, Sri Muthukumaran Medical College Hospital and Research Institute, Chikkarayapuram, Chennai – 600069, Tamil Nadu, India
*Corresponding author
Abstract:

Vitamins are essential for various biological responses in the human body and various researches indicated its role in immunity. With water soluble vitamins, B complex is being the most commonly prescribed supplements in clinical practice. This study was undertaken to find out in vitro effect of water soluble vitamin B complex against antibiotics commonly prescribed for respiratory infections caused by Klebsiella pneumoniae. 50 isolates of Klebsiella pneumoniae were isolated from sputum samples and their antibiotic sensitivity patterns were performed. 10 μl of commercially available solutions of Vitamin B complex were added along with antibiotics and incubated. The sensitivity pattern and zone diameters of antibiotics along with vitamins were recorded. The differences in zones were statistically analysed by student t test for significance. Out of 50 isolates of Klebsiella pneumoniae included in the study, there were six ESBL (Extended spectrum beta lactamase) producers. Vitamin B complex significantly enhanced the antibacterial activity of Imipenem, Piperacillin-tazobactam and decreased the antibacterial activity of Chloramphenicol in vitro. There exist significant interactions between water soluble Vitamin B complex and antibiotics in vitro as noted by Kirby-Bauer disc diffusion methods. This study can also be extended to research with multidrug resistant organisms.


Keywords: Antimicrobial activity of Vitamin B complex, Klebsiella pneumoniae.
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How to cite this article:

Sowmya Nasimuddin, Jeevan Malaiyan, Mohanakrishanan Kandaswamy, Swathithra Mohandass Nirmaladevi and Sumathi Gnanadesikan. 2017. An In Vitro Study of Effect of Water Soluble Vitamin B Complex on Antimicrobial Activity of Antibiotics against Klebsiella species Isolated from Respiratory Samples.Int.J.Curr.Microbiol.App.Sci. 6(10): 2782-2787. doi: https://doi.org/10.20546/ijcmas.2017.610.326