International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 6, Issue:10, October, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 2461-2473

Comparison of Anti CCP Positivity in RA and Other Arthritic Patients Including Connective Tissue Disorders
D. Ayisha*, Eunice Swarna Jacob and P. Shanmugapriya
Department of Microbiology, Thanjavur Medical College, Thanjavur, Tamil Nadu, India
*Corresponding author

Rheumatoid Arthritis (RA) is the most common systemic inflammatory, Auto immune Rheumatic disease of unknown etiology. Although the precise aetiology of RA remains unknown, there is strong evidence for autoimmunity, The present study is to evaluate the significance of AntiCCP antibodies in Rheumatoid Arthritis and to compare it with other Connective Tissue Disorders (CTD including SLE, and Osteo Arthritis (OA) and in Healthy Blood Donors as Control. From January 2016 to December 2016 a total number of 200 (each group50) subjects including both males and females were studied. Anti-CCP was positive in 39 of 50 RA patients (78%), 2 of 50 (4%) CTD (SLE) cases and none were positive among(50) OA and (50) HBD, Sensitivity and Specificity of AntiCCP test was 78% & 98.6% respectively and RF test results were positive in 38 of 50 RA patients (76%) 11 of 50 (22%) - CTD including    SLE patients , 6 of 50 (12%) - OA patients and  4 of 50 (8%) - of  HBD. Sensitivity and Specificity of RF test in RA was 76% and 86% respectively. In conclusion, based upon the higher sensitivity and specificity of the Anti CCP test in RA than other Connective Tissue Disorders including SLE, shows its significant association with RA. Thus it helps in distinguishing RA from other erosive disorders and excluding them from RA.

Keywords: Anti CCP positivity, Arthritic patients, Tissue disorder.

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How to cite this article:

Ayisha, D., Eunice Swarna Jacob and Shanmugapriya, P. 2017. Comparison of Anti CCP Positivity in RA and Other Arthritic Patients Including Connective Tissue Disorders.Int.J.Curr.Microbiol.App.Sci. 6(10): 2461-2473. doi:
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