National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Rheumatoid Arthritis (RA) is the most common systemic inflammatory, Auto immune Rheumatic disease of unknown etiology. Although the precise aetiology of RA remains unknown, there is strong evidence for autoimmunity, The present study is to evaluate the significance of AntiCCP antibodies in Rheumatoid Arthritis and to compare it with other Connective Tissue Disorders (CTD including SLE, and Osteo Arthritis (OA) and in Healthy Blood Donors as Control. From January 2016 to December 2016 a total number of 200 (each group50) subjects including both males and females were studied. Anti-CCP was positive in 39 of 50 RA patients (78%), 2 of 50 (4%) CTD (SLE) cases and none were positive among(50) OA and (50) HBD, Sensitivity and Specificity of AntiCCP test was 78% & 98.6% respectively and RF test results were positive in 38 of 50 RA patients (76%) 11 of 50 (22%) - CTD including SLE patients , 6 of 50 (12%) - OA patients and 4 of 50 (8%) - of HBD. Sensitivity and Specificity of RF test in RA was 76% and 86% respectively. In conclusion, based upon the higher sensitivity and specificity of the Anti CCP test in RA than other Connective Tissue Disorders including SLE, shows its significant association with RA. Thus it helps in distinguishing RA from other erosive disorders and excluding them from RA.
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