International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 6, Issue:10, October, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 2147-2153

Effect of Andrographolide Co-Administration on Pharmacokinetics of Meloxicam in Rats
V.L. Gondaliya Vaishali1, J.H. Patel1*, R.D. Varia1, S.K. Bhavsar1, P.D. Vihol Priti2, F.D. Modi Falguni1 and T.H. Solanki Tamanna1
1Department of Pharmacology and Toxicology
2Department of Veterinary Pathology, Veterinary College, Navsari Agricultural University, Navsari, Gujarat, India
*Corresponding author

The pharmacokinetic of meloxicam (5 mg/kg) and effect of co-administration of andrographolide (50 mg/kg) on pharmacokinetics of meloxicam were studied following intramuscular administration in rats. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). The mean peak plasma drug concentration of 30.48  1.44 mg/mL was achieved at 0.25 h. The pharmacokinetic parameters like mean absorption half-life (t½α) (9.71  0.3 h), elimination half-life (t½β) (12.14  0.006 h), apparent volume of distribution (Vdarea) (0.23  0.006 L/kg), area under plasma drug concentration-time curve (AUC0-∞) (383.85  8.68 g.h/mL), area under first moment curve (AUMC) (8813.72  145.23 g.h2/mL), total body clearance (ClB) (0.01  0.001 L/h/kg) and mean residence time (MRT) (22.63  0.36 h) were observed. Following co-administration of andrographolide with meloxicam after single intramuscular administration in rats, the mean peak plasma concentration of meloxicam was significantly decreased. The pharmacokinetic parameters like absorption half-life (t½Ka) and AUC0-ï‚¥were significantly increased whereas elimination half-life, Cmax and Vd were significantly decreased. This pharmacokinetic interaction might be due to drug-drug interactions.

Keywords: Andrographolide, Meloxicam, Pharmacokinetic, Interaction.

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How to cite this article:

Gondaliya Vaishali, V.L., J.H. Patel, R.D. Varia, S.K. Bhavsar, P.D. Vihol Priti, F.D. Modi Falguni and Solanki Tamanna, T.H. 2017. Effect of Andrographolide Co-Administration on Pharmacokinetics of Meloxicam in Rats.Int.J.Curr.Microbiol.App.Sci. 6(10): 2147-2153. doi:
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