National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Tuberculosis remains as one of the leading cause of morbidity and mortality globally. Estimated cases of around 9.6 million are affected by all forms of TB worldwide, out of which 2.2 billion are affected in India. India also has the second highest burden of MDR TB after China. Information on MDR TB is sparse in Raichur District. We undertook this study to detect MDR TB among MDR suspected cases and its common mutation using Genotype MTBDR plus. All presumptive MDR sputum samples were sent to DST LAB RIMS, Raichur from various part of Raichur district. Samples in study were taking during the period from January 2017 to April 2017. Line Probe Assay was done on sputum samples to detect common mutations in rpoB gene for Rifampicin and katG gene and inhA gene for Isoniazid resistance respectively. Out of the 448 samples received from MDR suspects, 49(10.9%) were found to be MDR TB. Commonest pattern for Rifampicin resistance was missing WT8 probe along with mutation in MUT3 band (S531L) codon, and mutation of MUT1 band (S5315T) of katG gene was commonest pattern for Isoniazid resistance. The MDR-TB among presumptive MDR in Raichur district was found to be 10.9%, and the mutation pattern obtained for Rifampicin and Isoniazid resistance were similar to those reported earlier.
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