Ravishankar"/> Ravishankar and Seetha Kunigal" /> Cefepime/Tazobactam – A Newer and Better β-Lactam/β-Lactamase Inhibitor Combination to Spare Carbapenem Drugs
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Original Research Articles                      Volume : 6, Issue:10, October, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 1379-1385
DOI: https://doi.org/10.20546/ijcmas.2017.610.163

Cefepime/Tazobactam – A Newer and Better β-Lactam/β-Lactamase Inhibitor Combination to Spare Carbapenem Drugs
Kalaivani Ramakrishnan1*, Sameera M. Jahagirdar2, M. Ravishankar2 and Seetha Kunigal1
1Department of Microbiology,
2Department of Anesthesiology, Mahatma Gandhi Medical College and Research Institute, SBV University, Pondicherry-607403, India
*Corresponding author

Gram negative pathogens acts as a significant etiological agent in causing both hospital and community acquired infections for the past few decades. Various resistance mechanisms, especially β-lactamases triggered extensive use of β-lactams. Carbapenems stands as the last resort to save many life threatening diseases. To prevent extensive Carbapenemases dissemination, this study was aimed to know the in vitro susceptibility pattern of Cefepime/tazobactam with carbapenems and other BL/BLI combinations. Between January and December 2015, with 947 non-repetitive Gram negative isolates from various respiratory samples (sputum, broncho-alveolar lavage, pleural fluid, endotracheal aspirates and throat swabs) this prospective study was done in a tertiary care hospital, Puducherry. Isolates were identified and antibiotic susceptibility testing was done with Cefepime/tazobactam and its results were compared with carbapenems and other BL/BLI combinations. Out of 947 isolates, E. coli (44%) was the predominant isolate identified, followed by Klebsiella spp. (27%) and others. The sensitivity pattern of all our Gram negative isolates towards Cefepime/tazobactam ranged from 59% to 100%. Towards carbapenems it ranged between 68%-100% and for other BL/BLI combinations 47%-100% susceptibility was observed. To overcome this emerged β-lactamase enzymes in hospital and community settings, appropriate and adequate antibiotic practices is needed. As there are very few new antibiotics in the pipe-line, antibiotic restriction policy will definitely reserve the high-end antibiotics for the future. We conclude that Cefepime/tazobactam will be a challenging combination almost equal to carbapenems and far better than other BL/BLI combinations in the practice.

Keywords: Cefepime/tazobactam, CPT, BL/BLI, ESBLs, Cefepime.

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How to cite this article:

Kalaivani Ramakrishnan, Sameera M. Jahagirdar, M. Ravishankar and Seetha Kunigal. 2017. Cefepime/Tazobactam – A Newer and Better β-Lactam/β-Lactamase Inhibitor Combination to Spare Carbapenem Drugs.Int.J.Curr.Microbiol.App.Sci. 6(10): 1379-1385. doi: https://doi.org/10.20546/ijcmas.2017.610.163
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.