International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 6, Issue:10, October, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 849-854

Tumor Necrosis Factor-Alpha and Interleukin-1 Beta in Febrile Seizures
Amr Mohamed El-Sabbagh1*, Samah Sabry El-Kazzaz1, Ghada El-Saeed Mashaly1, Dina Salama Abd Elmagid2 and Noha Tharwat2
1Department of Medical Microbiology and Immunology,
2Department of Pediatrics, Faculty of Medicine, Mansoura University, Egypt
*Corresponding author

Febrile seizures happening between 6 months and 5 years are considered the most prevalent form of childhood seizures. It is defined as seizures occurring during fever in children without central nervous system infection. Pro-inflammatory cytokines released during infection play an essential role in the mechanism of febrile seizures. Studies try to clear the responsibility of these pro-inflammatory cytokines in the pathogenesis of febrile seizures. Among these cytokines, interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) have important roles in the pathogenesis of febrile seizures with contradictory results. In our study we aimed to identify the relation between serum TNF-α, IL-1β and febrile seizures. The study included ninety patients, with an age range between 6 months and 5 years, who were taken consecutively from the out-patient clinic and emergency department of Mansoura University Children Hospital “MUCH” between June 2015 and August 2016. Forty children presented with febrile seizures, 30 children presented with fever without seizures and 20 patients with seizures without fever. Blood sample was taken from patients with febrile seizures and also from those with afebrile seizures within half hour of the time of the convulsion, then we measured serum TNF-α and IL-1β levels by ELISA technique. Also, samples were taken from patients with fever but without seizures then they were similarly studied. Serum IL-1β and TNF-α level were higher in children with febrile seizure than in those with fever only (significant P value< 0.05). Their serum levels were also higher in afebrile seizure children than those with febrile illness only and lower than febrile seizure patients with no significant P value. Our study supports that the increased production of TNF-α andIL-1β is positively concomitant with the occurrence of febrile seizures.

Keywords: Febrile seizures, Interleukin-1beta and Tumor necrosis factor-alpha.

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How to cite this article:

Amr Mohamed El-Sabbagh, Samah Sabry El-Kazzaz, Ghada El-Saeed Mashaly, Dina Salama Abd Elmagid and Noha Tharwat. 2017. Tumor Necrosis Factor-Alpha and Interleukin-1 Beta in Febrile Seizures.Int.J.Curr.Microbiol.App.Sci. 6(10): 849-854. doi:
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