International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 6, Issue:10, October, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 669-677

Study of Microorganisms Causing Neonatal Sepsis in a Tertiary Care Hospital and their Antimicrobial Susceptibility Pattern
Sabharritha Sekar1, David Agatha2* and R. Selvi3
1Department of Paediatrics, Kilpauk Medical College, Chennai-10, Tamil Nadu, India
2Institute of Microbiology, Madras Medical College, Chennai-3, Tamil Nadu, India
3Department of Microbiology, Stanley Medical College, Chennai-1, Tamil Nadu, India
*Corresponding author

Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life. It encompasses various systemic infections of the newborn such as septicemia, meningitis, pneumonia, arthritis, osteomyelitis and urinary tract infections. A total of 50 suspected cases of Neonatal sepsis in a Tertiary care hospital were studied for 2 months (August 2011-September 2011). Blood samples obtained from cases of neonatal sepsis were cultured to analyse for bacteriological profile and antibiotic sensitivity pattern. Gram negative bacterial isolates obtained were analysed for extended spectrum beta lactamase (ESBL) production and Staphylococcus aureus and Coagulase negative staphylococci (CONS) isolates obtained were analysed for methicillin resistance by phenotypic method. Out of the 50 blood samples collected blood culture was positive in 31(62%) and 31 bacterial isolates were obtained. Out of the 31 bacterial isolates 26(83.88%) were gram negative bacteria and 5(16.12%) were gram positive bacteria. Twelve (46.15%) of the 26 gram negative bacteria were ESBL producers. All the ESBL producers (100%) were sensitive to imipenem. One (50%) of 2 Staphylococcus aureus and 2(66.67%) of the 3 CONS were methicillin resistant. All the methicillin resistant Staphylococcus aureus and CONS were sensitive to vancomycin. This study emphasizes the need for routine bacterial surveillance and study of their resistance pattern in neonatal care for implementation of a rational empirical treatment strategy.

Keywords: Neonatal sepsis, Blood culture, MRSA, ESBL, Phenotypic confirmatory test.

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Sabharritha Sekar, David Agatha and Selvi, R. 2017. Study of Microorganisms Causing Neonatal Sepsis in a Tertiary Care Hospital and their Antimicrobial Susceptibility Pattern.Int.J.Curr.Microbiol.App.Sci. 6(10): 669-677. doi:
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