International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 6, Issue:10, October, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(10): 661-668

Assessment of Human Herpes Virus 8 Infection among Breast Cancer Patients
Amira S. Mohamed1, Hanaa H.A. Gomaa1 and Fadia M. Attia2
1Department of Botany, Faculty of Science, Suez Canal University, Ismailia, Egypt
2Department Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
*Corresponding author

In several published studies, viruses have been implicated in the pathogenesis of breast cancers. Human Herpes virus 8 (HHV-8) has recently emerged as causal factors of human breast cancers. This study aims to assess the prevalence of HHV-8 DNA in women with breast cancer. HHV-8 DNA was detected using Real-Time PCR in EDTA-treated whole blood samples obtained from 45 breast cancer patients in Suez Canal University Hospital. HHV-8 DNA was detected in 13(28.8%) patients. The prevalence of HHV-8 increased with increasing tumor grade (0% for grade I, 50% and 100% for grades II and III, respectively). The prevalence of HHV-8 DNA was higher (12 out of 12; 100%) in patients with lymph node (LN) metastasis compared lymph node-negative patients (1 out of 33; 3 %). The prevalence of HHV-8 infection increased significantly with increasing tumor grade and LN metastasis suggesting that HHV-8 may be a contributing factor to breast cancer progression and metastasis.

Keywords: Breast Cancer, Human Herpes virus 8 (HHV-8), HHV-8 DNA.

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How to cite this article:

Amira S. Mohamed, Hanaa H.A. Gomaa and Fadia M. Attia. 2017. Assessment of Human Herpes Virus 8 Infection among Breast Cancer Patients.Int.J.Curr.Microbiol.App.Sci. 6(10): 661-668. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.