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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 266-274
DOI: http://dx.doi.org/10.20546/ijcmas.2016.505.029


Study of Hepatic Steatosis Index in Patients with Chronic HCV Infection
Nadia Elwan1, Asem Elfert1, Sherief Abd-Elsalam1*, Ayman Alska2, Abdelrahman Kobtan1, Mohamed Yousef1, Samah Mosaad1, Osama Al-shourbgy1 and Mohammed Elhendawy1
1Tropical Medicine and Infectious Diseases Department, Tanta University, Tanta, Egypt
2Pathology Department, Tanta University, Tanta, Egypt
*Corresponding author
Abstract:

Hepatic steatosis is a frequent cause for elevated serum aminotransferase levels. The main screening method is ultrasonography. A combination of non-invasive tests may help in the diagnostic evaluation of a patient with suspected steatosis. Liver biopsy is the gold standard to precisely diagnose NASH. In this study we assessed the usefulness of hepatic steatosis index in comparison with ultrasonography and histopathological examination in the evaluation of steatosis associated with HCV infection. This study was carried out at Tropical medicine department (Tanta University Hospital). We studied fifty HCV patients who have bright liver in ultrasound. All patients were further studied with histopathological examination of liver biopsy as well as lab investigations. Hepatic steatosis index was also calculated. A significant positive correlation has been found between hepatic steatosis index (HSI) and Metavir staging of fibrosis assessed by histopathological examination. When the mean value of HSI = 35.5, the stage was F0 and when the mean value of HSI = 43.7, the stage was F3. A significant positive correlation has also been found between hepatic steatosis index and histopathological grading of steatosis. When the mean value of HSI = 31.7, the grade was G0 and when the mean value of HSI = 39.1, the grade was G3. Hepatic steatosis index may offer an economical noninvasive tool for predicting of hepatic steatosis with reasonable accuracy. In practice, the index could be used for the detection of risky patients in order to offer more advanced investigation, nutrition and life style counselling, as well as for the detection of severe steatotic patients requiring medical supervision and therapy.


Keywords: HCV,Fibrosis,Steatosis,Hepatic steatosis index.
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How to cite this article:

Nadia Elwan, Asem Elfert, Sherief Abd-Elsalam, Ayman Alska, Abdelrahman Kobtan, Mohamed Yousef, Samah Mosaad, Osama Al-shourbgy and Mohammed Elhendawy. 2016. Study of Hepatic Steatosis Index in Patients with Chronic HCV Infection.Int.J.Curr.Microbiol.App.Sci. 5(5): 266-274. doi: http://dx.doi.org/10.20546/ijcmas.2016.505.029