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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(4): 969-975
DOI: http://dx.doi.org/10.20546/ijcmas.2016.504.110


Validity of TNFRII Polymorphism in Susceptibility and Severity of Rheumatoid Arthritis Iraqi Patients
Wasnaa J. Mohammed, Mohammed Sh. Jabur, Nizar Ab. Jasim and Basim Sh
Wasnaa J. Mohammed1, Mohammed Sh. Jabur2*, Nizar Ab. Jasim3 and Basim Sh4
*Corresponding author
Abstract:

Tumor necrosis factor (TNFα) plays an important role in autoimmune pathogenesis and is the main therapeutic target of rheumatoid arthritis (RA). TNFα signals via 2 receptors, TNF type 1(TNFRI) and (TNFRII) signaling are mainly activated by membrane TNF (m TNFα). The present study was aimed to investigate the role of TNF – α RII gene polymorphisms in susceptibility and severity of rheumatoid arthritis. Fifty RA patients and 50 apparently healthy controls were enrolled in the study. Genotyping of 196M/R polymorphism of TNFRII gene was determined by PCR-RFLP. Results were suggested that TNFRII196M/R polymorphism were associated with RA susceptibility. There was a significant difference in the genotype frequencies polymorphism of the TNFRII 196M/R between control and RA patients (p<0.05) (p<0.01).


Keywords: Rheumatoid arthritis,TNFRII polymorphism, Susceptibility, Severity.
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How to cite this article:

Wasnaa J. Mohammed, Mohammed Sh. Jabur, Nizar Ab. Jasim and Basim Sh. 2016. Validity of TNFRII Polymorphism in Susceptibility and Severity of Rheumatoid Arthritis Iraqi Patients.Int.J.Curr.Microbiol.App.Sci. 5(4): 969-975. doi: http://dx.doi.org/10.20546/ijcmas.2016.504.110