Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(4): 929-934
DOI: http://dx.doi.org/10.20546/ijcmas.2016.504.105


Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Centre, Kerala, India
I.R. Regha*, Deepa Harichandran and B. Sulekha
Department of Microbiology , Sree Narayana Institute of Medical Sciences,Chalakka, Ernakulam, Kerala, India
*Corresponding author
Abstract:

Drug resistance among Staphylococcus aureus is an increasing problem. Clindamycin is one of the  effective antibiotic for treating  both methicillin sensitive and resistant Staphylococcal infections. A major concern regarding the use of clindamycin therapy is the presence of inducible resistance. In vitro routine tests for clindamycin susceptibility may fail to detect inducible resistance resulting in treatment failure. The present study aimed to find out the  inducible clindamycin resistance in the clinical isolates of Staphylococcus aureus  using D test.  The study was conducted at the Department of Microbiology in Sree Narayana Institute of Medical Sciences, Kerala over a period of one year. All of the total 220 S.aureus  isolates  during the  period were included in the study. D test was done in the erythromycin resistant strains as per CLSI guidelines. Inducible clindamycin resistance was observed in 12.7%, constitutive resistance in 8.1% and MS phenotype in 41.8% of the total isolates. The rate of MRSA and MSSA were  41.8% and 58.2% respectively. Inducible resistance and constitutive resistance were higer in MRSA (34.8% and 10.9%  respectively) as compared to MSSA where the inducible resistance was only 3.1% and  no constitutive resistance was noticed. 19.6% of MRSA and 21.9% of MSSA showed MS phenotype. Inducible clindamycin resistance was more common than constitutive  resistance  in our hospital. Both inducible and constitutive resistance showed higher incidence among MRSA than MSSA. The trends in resistance may vary from place to place. So D- test should be done routinely to delineate different  resistant phenotypes in the laboratory to help clinicians for  the judicious use of clindamycin in order to avoid therapeutic failure  as well as irrational use of higher antibiotics.


Keywords: Clindamycin,D test, MLSB phenotype, Staphylococcus aureus.
Download this article as Download

How to cite this article:

Regha, I. R., Deepa Harichandran and Sulekha, B. 2016. Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Centre, Kerala, India.Int.J.Curr.Microbiol.App.Sci. 5(4): 929-934. doi: http://dx.doi.org/10.20546/ijcmas.2016.504.105