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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(4): 279-286
DOI: http://dx.doi.org/10.20546/ijcmas.2016.504.032


Antibiotic Susceptibility Pattern and Extended Spectrum Beta Lactamase among Klebsiella pneumoniae isolates in a Tertiary Care Centre
B. U. Sunitha1* and B. V. Navaneeth2
1Department of Microbiology, Shridevi Institute of Medical Sciences and Research Hospital, Sira Road, NH-04, Tumkur-572106, Karnataka, India
2Department of Microbiology, ESIC-MC-PGIMSR, Rajajinagar,Bengaluru-560010, India
*Corresponding author
Abstract:

Extended spectrum beta-lactamase –Klebsiella pneumoniae (ESBL -KP) is one of the leading causes of nosocomial infections seen with increasing prevalence worldwide. The present study was undertaken to know the prevalence of ESBL-KP and their antibiotic susceptibility pattern and to create a baseline antibiotic resistance data to implement effective infection control policy. A total of 225 non duplicate K. pneumoniae isolates were obtained from various clinical samples over a period of 18 months. Antibiotic susceptibility testing and ESBL detection was done by Kirby Bauer’s disc diffusion and CLSI methods respectively. Highest resistance of 91.5% was noted to amoxicillin-clavulanic acid.  Least resistance was recorded to imipenem (24.4%) and amikacin (39.1%). Resistance of > 85% was noted to third generation cephalosporins [85.7% each to cefotaxime and ceftriaxone; ceftazidime (91%)].ESBL positivity was 46.6%. ICU, wards and outpatient isolates revealed ESBLs of 51.3%, 39.7% and 52.7% respectively. Multi-drug resistance was 60%.Antibiotic resistance was higher in ICU isolates. Imipenem and amikacin may be preferred antibiotics in treating K pneumoniae infections.


Keywords: Klebsiella pneumoniae, Nosocomial Infections, Extended-Spectrum Beta Lactamases,Multidrug Resistance.
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How to cite this article:

Sunitha, B. U., and Navaneeth, B. V. 2016. Antibiotic Susceptibility Pattern and Extended Spectrum Beta Lactamase among Klebsiella pneumoniae isolates in a Tertiary Care Centre.Int.J.Curr.Microbiol.App.Sci. 5(4): 279-286. doi: http://dx.doi.org/10.20546/ijcmas.2016.504.032