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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(6): 2360-2368
DOI: https://doi.org/10.20546/ijcmas.2017.606.280


Interferon Gamma Release Assay and Tuberculin Skin Test in the Diagnosis of Latent Tuberculosis among Health Care Workers – A Comparative Study
Reshmi Gopalakrishnan1* and G.S. Vijay Kumar2
1Assistant professor, Department of Microbiology, Malabar Medical College Hospital and Research Centre, Calicut, Kerala
2Professor and Head of Microbiology, Kodagu Institute of Medical Science, Madikeri, Karnataka
*Corresponding author
Abstract:

Health Care Workers (HCWs) are vulnerable to tuberculosis exposure. Non availability of a reliable test has resulted in underestimation of latent tuberculosis infection (LTBI) among HCWs. The aim is to detect the rate of LTBI among nursing and medical students, Compare Interferon Gamma Release Assay (IGRA) and Tuberculin Skin Test (TST), Detect conversions and reversions. Total of 100 (83 nursing and 17 medical) students were included in the study. QuantiFERON®-TB Gold In-Tube test (QFT) and TST were carried out for the participants and results at various thresholds were noted. The prevalence of LTBI was found to be 16 - 26% among the students using TST and 7 – 8% using QFT. TST The conversion was 2.5% for TST and 2.5 % for QFT when thresholds were kept low. The conversion was 7.5% for TST and 2.5 % for QFT, with stringent threshold. With low thresholds, 25% students had reversions and with stringent threshold values 20% had reversion. No single test is reliable for detecting LTBI. Routine TST and IGRA of HCWs with patient contact should be part of the screening program with a major effort to institute treatment for LTBI.


Keywords: Latent tuberculosis infection, Healthcare workers, Interferon gamma release assay.
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How to cite this article:

Reshmi Gopalakrishnan and Vijay Kumar, G.S. 2017. Interferon Gamma Release Assay and Tuberculin Skin Test in the Diagnosis of Latent Tuberculosis among Health Care Workers – A Comparative StudyInt.J.Curr.Microbiol.App.Sci. 6(6): 2360-2368. doi: https://doi.org/10.20546/ijcmas.2017.606.280