National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) gram-negative bacilli (GNB) are a leading cause of healthcare associated infections worldwide and pose a growing threat to antimicrobial therapy in Indian tertiary care hospitals. To determine the prevalence and resistance pattern of MDR/XDR gram-negative bacilli isolated from inpatients and outpatients at a tertiary care hospital in Telangana over a one year period. This retrospective, descriptive study analyzed 146 multidrug-resistant gram negative clinical bacterial isolates recorded in the hospital’s antimicrobial resistance surveillance registry between June 2025 and May 2026. Organism identification and antimicrobial susceptibility testing were performed by standard microbiological methods as per CLSI guidelines 2025edition; isolates were categorized as MDR, XDR or pandrug-resistant (PDR) using the Magiorakos et al., international consensus definitions. Of 591 total gram negative bacilli 146 (24.7%) gram-negative bacilli were MDROs. Of which Klebsiellapneumoniae (56, 38.4%) and Escherichia coli (50, 34.2%) were the predominant organisms, followed by Pseudomonas aeruginosa (19, 13.0%) and Acinetobacterbaumannii (10, 6.8%). Among GNB isolates, 117 (80.1%) were XDR and 29 (19.9%) were MDR (non-XDR); XDR rates were highest for A. baumannii (100%), P. aeruginosa (89.5%) and K. pneumoniae (89.3%). Inpatients contributed 99 (67.8%) of GNB isolates. Urine (37.0%) and blood (13.7%) were the leading specimen types, and Nephrology, Internal Medicine and Plastic Surgery were the leading contributing departments. Gram-negative bacilli, particularly K. pneumoniae and E. coli, constitute the predominant reservoir of multidrug resistance in this tertiary care setting, with a strikingly high XDR burden. These findings underscore the urgent need for robust antimicrobial stewardship, infection-control measures, and judicious, susceptibility-guided use of novel beta-lactam/beta-lactamase-inhibitor combinations.
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