National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study reports the isolation and characterization of a novel actinomycete strain, designated as MS1, obtained from sediment samples collected at Mangrove Forest. Upon serial dilution, three identical colonies of actinomycetes were identified, with further analysis focusing on the MS1 strain. Subsequent investigations, MS1 exhibited superior growth compared to the standard ISP2 medium, suggesting its potential as a robust biotechnological resource. Furthermore, MS1 displayed significant antioxidant properties, as evidenced by DPPH radical scavenging, metal chelating activity, and ABTS assay, with comparisons to standard antioxidants underscoring its efficacy. The estimation of total phenolic content further supported MS1's antioxidant potential. Importantly, MS1 exhibited promising anticancer activity against A549 cell lines, with a dose-dependent decrease in cancer cell viability observed. At a concentration of 100 µg/ml, MS1 extract demonstrated a notable reduction in cancer cell viability (16%), highlighting its potential as an anticancer agent. Overall, these findings suggest that strain MS1 harbors valuable bioactive compounds with diverse applications in pharmaceutical and biotechnological industries, warranting further investigation into its biochemical and genetic characteristicsactivity against A549 cell lines, with a dose-dependent decrease in cancer cell viability observed. At a concentration of 100 µg/ml, MS1 extract demonstrated a notable reduction in cancer cell viability (16%), highlighting its potential as an anticancer agent. Overall, these findings suggest that strain MS1 harbors valuable bioactive compounds with diverse applications in pharmaceutical and biotechnological industries, warranting further investigation into its biochemical and genetic characteristics.
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