National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Multidrug-resistant bacterial and fungal pathogens associated with burn wound infections represent a significant therapeutic challenge, highlighting the need for alternative or complementary antimicrobial strategies. This study evaluated the antimicrobial potential of an ethanolic extract of corn silk (Zea mays L.) against multidrug-resistant clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans. Clinical isolates previously recovered from secondary burn wound infections were cultured on selective and differential media and identified using standard microbiological and biochemical methods. Corn silk was processed by washing, blanching, air-drying, grinding, and ethanolic extraction under orbital shaking at room temperature for 48 h. The antimicrobial activity of the extract, alone and in combination with selected antimicrobial agents, was assessed using a modified disk diffusion method. Inhibition-zone diameters were measured to compare the activity of the individual treatments and combinations. In addition, molecular docking analysis was performed to investigate the interaction of maysin, a reported corn-silk constituent, with the PelBC outer-membrane exopolysaccharide transporter of P. aeruginosa. Docking analysis was conducted using PyMOL and MzDOCK, with a reported binding-affinity value of −11.6. Increases in inhibition-zone diameter were considered descriptive evidence of enhanced antimicrobial activity rather than definitive proof of synergy. Overall, the study provides an experimental framework for evaluating ethanolic corn silk extract as a potential adjunct to conventional antimicrobial agents against multidrug-resistant pathogens associated with burn wound infections.
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