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ICV 2023: 95.56
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Original Research Articles Volume : 15, Issue : 7, July, 2026

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Int.J.Curr.Microbiol.App.Sci.2026.15(7) : 9-19
DOI : https://doi.org/10.20546/ijcmas.2026.1507.002


Bacteriological Spectrum and Antimicrobial Resistance Burden of Bloodstream Infection Isolates in Intensive Care Unit Patients

T. Vidhya* and Deepali M. Kulkarni
Department of Microbiology, Swami Ramanand Teerth Rural Government Medical College, Ambajogai, Maharashtra, India
*Corresponding author
Abstract:

Bloodstream infections (BSIs) are a significant cause of morbidity and mortality in intensive care unit (ICU) patients. In hospital settings, bloodstream infections are associated with mortality rates of approximately 16% in general wards and 40% in intensive care units. This study aimed to identify the bacterial isolates causing BSIs in the ICU and their antimicrobial susceptibility profiles. A cross-sectional observational study was conducted on 224 patients with clinically diagnosed BSI in the ICU between December 2017 and October 2019. Blood samples were collected and subjected to culture. Isolates were identified using conventional methods, and antimicrobial susceptibility testing was performed using the modified Kirby-Bauer disc diffusion method. Of the 224 samples, 54 (24.10%) were culture-positive, with a higher prevalence in males (57.40%) and the age group of 51-60 years (29.63%). Gram-positive bacteria (55.56%) were more common than gram-negative bacilli (37.04%). The most common isolates were coagulase-negative staphylococci (CoNS) (37.03%), Klebsiella pneumoniae (14.82%), Staphylococcus aureus (12.97%), and Escherichia coli (11.12%). Gram-positive isolates showed high susceptibility to vancomycin and linezolid, while gram-negative isolates were highly susceptible to imipenem and piperacillin-tazobactam. Methicillin resistance was observed in 57% of S. aureus and 55% of CoNS isolates. Among the gram-negative isolates, 50% were extended-spectrum beta-lactamase (ESBL) producers and 20% were metallo-beta-lactamase (MBL) producers. This study highlights the importance of early recognition and prompt initiation of appropriate antimicrobial therapy to reduce morbidity and mortality associated with BSIs in ICU patients. Continuous surveillance and adherence to antimicrobial stewardship are crucial to combat the emerging threat of antibiotic resistance.


Keywords: Bloodstream infections (BSIs), Intensive care unit (ICU), Bacteriological Profile and Susceptibility profile

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How to cite this article:

Vidhya T. and Deepali M. Kulkarni. 2026. Bacteriological Spectrum and Antimicrobial Resistance Burden of Bloodstream Infection Isolates in Intensive Care Unit Patients. Int.J.Curr.Microbiol.App.Sci. 15(7): 9-19 doi: https://doi.org/10.20546/ijcmas.2026.1507.002
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