Antibiotic Resistance of Enterobacteriaceae strains isolated from Urine at the Mother and Child University Hospital in N'Djamena, Chad
Mahamat Koulbou Abdoulaye1,2, Hassan Mahamat Ali
4, Oumar Ouchar Mahamat
2,6, Ali Haroun Hissein
5, Fissou Henry Yandai
3,7, Naibi Keitoyo Amede
7, Lodoum Josué
1, Mouktar Abaya
2, Djamaladine Mahamat Doungous
8, Mahamat Nour Djibrine Abakar
6,9, Abdelsalam Tidjani
5,6,9, Mahamat Béchir
3,6 et Ali Mahamat Moussa
3,6
1Formation Doctorale Biologie et Santé Humaine de l’Université de Ndjamena/Tchad BP : 1117, Avenue Mobutu, Chad 2Laboratoire de Bactériologie du Centre Hospitalier Universitaire de la Mère et de l’Enfant de Ndjamena/Tchad, BP : 6667, Avenue du General De Gaulle, Chad 3Institut National de Santé Publique du Tchad, BP : Avenue Maldom Bada, Chad 4Laboratoire de Biosûreté et des Épidémies, Ministère de la Santé publique et de la prévention, N’Djamena, Tchad, BP, Avenue 5Laboratoire de Recherche Diagnostics et Expertises Scientifique, Département de Santé Publique de l’Université de Ndjamena, BP : 1117 Avenue Mobutu, Chad
6Faculté de Sciences de la Santé Humaine, Université de N’Djamena, N’Djamena, Tchad BP : 1117 Avenue Mobutu, Chad 7Institut de Recherches en Elevage pour le Développement BP : 433, Route de Farcha, Chad 8Département des Sciences Biomédicales et Pharmaceutiques, Institut National Supérieur des Sciences et Techniques d’Abéché, Abéché, Tchad BP 130, Chad 9Centre Hospitalier Universitaire de la Mère et de l’Enfant de Ndjamena/Tchad, BP : 6667, Avenue du General De Gaulle
*Corresponding author
Abstract:
Infections caused by multidrug-resistant bacteria represent a major challenge to healthcare systems worldwide, particularly in the management of urinary tract infections (UTIs), which are among the most common bacterial infections in both community and hospital settings. This study aimed to investigate the antimicrobial resistance profile of Enterobacteriaceae isolated from urine samples collected at the Mother and Child University Hospital Center (CHU-ME), N'Djamena, Chad. A prospective descriptive study was conducted from June 2024 to February 2026, involving 7,051 urine samples. Bacterial isolation and identification were performed using conventional microbiological methods, the API 20E system, and antimicrobial susceptibility testing according to CA-SFM/EUCAST 2024 guidelines. Among the samples analyzed, 171 (2.4%) yielded positive cultures. Female patients accounted for 60% of cases, and the most affected age group was 21–40 years. High resistance rates were observed to ampicillin (70%), cefotaxime (48.2%), ceftriaxone (43.3%), and ciprofloxacin (44.2%). Resistance to carbapenems was detected in 6.4% of isolates, while multidrug-resistant and ESBL-producing strains were also identified. The findings highlight the emergence of antimicrobial resistance among uropathogens and emphasize the need for continuous surveillance and effective antibiotic stewardship programs.
Keywords:
ECBU, Résistance, Bactérie, CHU-ME, Tchad
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How to cite this article:
Mahamat Koulbou Abdoulaye, Hassan Mahamat Ali, Oumar Ouchar Mahamat, Ali Haroun Hissein, Fissou Henry Yandai, Naibi Keitoyo Amede, Lodoum Josué, Mouktar Abaya, Djamaladine Mahamat Doungous, Mahamat Nour Djibrine Abakar, Abdelsalam Tidjani, Mahamat Béchir
et Ali Mahamat Moussa. 2026. Résistance aux antibiotiques des souches d Entérobactérie isolé des urines au CHU de la Mère et l’Enfant à N’Djamena, Tchad.
Int.J.Curr.Microbiol.App.Sci.
15(6): 1-13
doi:
https://doi.org/10.20546/ijcmas.2026.1506.001
Citations
National Academy of Agricultural Sciences (NAAS) 
