National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Fenugreek (Trigonella foenum-graecum L.) is a multifunctional herb of the Fabaceae family, widely cultivated across the Mediterranean, North Africa, Asia, and Europe. Yemeni fenugreek is traditionally valued for its unique nutritional and bioactive composition. This narrative review synthesizes evidence on its chemical profile, health benefits, culinary applications, and safety. The seeds are rich in proteins, carbohydrates, dietary fiber, essential vitamins and minerals, and bioactive compounds, including diosgenin, trigonelline, 4-hydroxyisoleucine, saponins, and flavonoids, which confer antidiabetic, hypolipidemic, antioxidant, and anti-inflammatory effects. Clinical trials and meta-analyses demonstrate improvements in glycemic control and lipid profiles, while its high fiber and gum content facilitate diverse functional food applications. Reported adverse effects mainly gastrointestinal disturbances, allergic reactions, and potential drug interactions highlight the need for cautious use. Comparative data suggest Yemeni fenugreek may offer superior bioactivity, though further longitudinal and region-specific studies are required to substantiate traditional claims and optimize its therapeutic and functional food potential.
A?agündüz, D., ?ahin, T. Ö., Y?lmaz, B., Ekenci, K. D., Duyar Özer, ?., & Capasso, R. (2022). Cruciferous vegetables and their bioactive metabolites: from prevention to novel therapies of colorectal cancer. Evidence?Based Complementary and Alternative Medicine, 2022(1), 1534083.https://doi.org/10.1155/2022/1534083
Al Mosawi, A. J. (2021). The use of fenugreek supplementation in diabetes. Glob J Obes Diabetes Metab Syndr, 8(2), 10–13.
Almatroodi, S. A., Almatroudi, A., Alsahli, M. A., & Rahmani, A. H. (2021). Fenugreek (Trigonella foenum-graecum) and its active compounds: a review of its effects on human health through modulating biological activities.
Al-Sebaeai, M. A., Alfawaz, M., Chauhan, A. K., Al-Farga, A., & Fatma, S. (2017a). Physicochemical characteristics and nutritional value of fenugreek seeds and seed oil. Int J Food Sci Nutr, 2, 52–55.
Al-Sebaeai, M. A., Alfawaz, M., Chauhan, A. K., Al-Farga, A., & Fatma, S. (2017b). Physicochemical characteristics and nutritional value of fenugreek seeds and seed oil. Int J Food Sci Nutr, 2, 52–55.
Al-Sebaeai, M. A., Alfawaz, M., Chauhan, A. K., Al-Farga, A., & Fatma, S. (2017c). Physicochemical characteristics and nutritional value of fenugreek seeds and seed oil. Int J Food Sci Nutr, 2, 52–55.
Askarpour, M., Alami, F., Campbell, M. S., Venkatakrishnan, K., Hadi, A., & Ghaedi, E. (2020). Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials. Journal of Ethnopharmacology, 253, 112538. https://doi.org/10.1016/j.jep.2020.112538
Aurich, S., Spiric, J., Engin, A., Simon, J. C., Mahler, V., & Treudler, R. (2019). Report of a case of IgE-mediated anaphylaxis to fenugreek. Journal of Investigational Allergology and Clinical Immunology, 29(1), 56–58. https://doi.org/10.18176/jiaci.0304
Badraoui, R., Al-Hazmi, Y., Brahmi, F., Ben-Nasr, H., Noumi, E., Bouali, N., Adnan, M., Siddiqui, A. J., De Feo, V., & Snoussi, M. (2025). Pharmacokinetic and phytochemical screening of Allium subhirsutum leaves for antimicrobial and anti-inflammatory properties. Scientific Reports, 15(1), 34806. https://doi.org/10.1038/s41598-025-34806-0
Balodi, B. (1991). The genus Trigonella L.(Fabaceae) in the northwest Himalaya. J. Econ. Tax. Bot., 5, 11–16.
Banyal, S., Kumari, A., Luthra, A., & Kundu, S. (2022). Utilization and Evaluation of Fenugreek (Trigonella foenum graecum) Gum as a stabilizer in ice cream. Annals: Food Science & Technology, 23(2).
Bentele-Jaberg, N., Guenova, E., Mehra, T., Nägeli, M., Chang, Y.-T., Cozzio, A., French, L. E., & Hoetzenecker, W. (2015). The phytotherapeutic fenugreek as trigger of toxic epidermal necrolysis. Dermatology, 231(2), 99–102. https://doi.org/10.1159/000431329
Bienkowski, T., Zuk-Golaszewska, K., Kaliniewicz, J., & Golaszewski, J. (2017). Content of biogenic elements and fatty acid composition of fenugreek seeds cultivated under different conditions. Chilean Journal of Agricultural Research, 77(2), 134–141. https://doi.org/10.4067/S0718-58392017000200134
Boullata, J. I., & Nace, A. M. (2000). Safety issues with herbal medicine. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 20(3), 257–269. https://doi.org/10.1592/phco.20.4.257.34886
Branch, S. (2013). Fenugreek (Trigonella foenum-graecum L.) as a valuable medicinal plant. International Journal of Advanced Biological and Biomedical Research, 1, 922–931.
Chantry, C. J., Howard, C. R., Montgomery, A., & Wight, N. (2004). Use of glactogogues in initiating or augmenting maternal milk supply. The Academy of Breastfeeding Medicine, 6(1), 41–49.
Doolabh, K., Finnegan, D., Pehlivan, N., & Farrand, S. (2019). Oral fenugreek seed consumption and serotonin syndrome. Australian & New Zealand Journal of Psychiatry, 53(12), 1225. https://doi.org/10.1177/0004867419876855
Duke, J. (2012). Handbook of legumes of world economic importance. Springer Science & Business Media.
Ebo, D. G., Bridts, C. H., Mertens, M. H., & Stevens, W. J. (2006). Coriander anaphylaxis in a spice grinder with undetected occupational allergy. Acta Clinica Belgica, 61(3), 152–156. https://doi.org/10.1179/acb.2006.025
Eghbaljoo, H., Sani, I. K., Sani, M. A., Rahati, S., Mansouri, E., Molaee-Aghaee, E., Fatourehchi, N., Kadi, A., Arab, A., & Sarabandi, K. (2022). Advances in plant gum polysaccharides; Sources, techno-functional properties, and applications in the food industry-A review. International Journal of Biological Macromolecules, 222, 2327–2340. https://doi.org/10.1016/j.ijbiomac.2022.09.110
El Nasri, N. A., & El Tinay, A. H. (2007). Functional properties of fenugreek (Trigonella foenum graecum) protein concentrate. Food Chemistry, 103(2), 582–589. https://doi.org/10.1016/j.foodchem.2006.09.003
Faisal, Z., Irfan, R., Akram, N., Manzoor, H. M. I., Aabdi, M. A., Anwar, M. J., Khawar, S., Saif, A., Shah, Y. A., & Afzaal, M. (2024a). The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications. Food Science & Nutrition, 12(4), 2294–2310.
Faisal, Z., Irfan, R., Akram, N., Manzoor, H. M. I., Aabdi, M. A., Anwar, M. J., Khawar, S., Saif, A., Shah, Y. A., & Afzaal, M. (2024b). The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications. Food Science & Nutrition, 12(4), 2294–2310. https://doi.org/10.1002/fsn3.2294
Frangopoulos, T. (2022). A green, efficient approach on extraction of polyphenols from fenugreek seeds (Trigonella foenum-graecum): DES and β-cyclodextrin assisted extraction. Waste and Biomass Valorization, 13(11), 4403–4415. https://doi.org/10.1007/s12649-022-01735-4
Gaddam, A., Galla, C., Thummisetti, S., Marikanty, R. K., Palanisamy, U. D., & Rao, P. V. (2015). Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes. Journal of Diabetes & Metabolic Disorders, 14(1), 74. https://doi.org/10.1186/s40200-015-0207-2
Gavarti, M. B., Askari, A., Roohafza, H., Askari, M., Jervekani, Z. T., Kaveh, S., Kermanialghoraishi, M., Sadeghimahoonak, A., & Sadeghi, M. (2025). The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical trial. Phytomedicine Plus, 5(1), 100691. https://doi.org/10.1016/j.phyplu.2025.100691
Haber, S. L., & Keonavong, J. (2013a). Fenugreek use in patients with diabetes mellitus. American Journal of Health-System Pharmacy, 70(14), 1196–1203. https://doi.org/10.2146/ajhp120320
Haber, S. L., & Keonavong, J. (2013b). Fenugreek use in patients with diabetes mellitus. American Journal of Health-System Pharmacy, 70(14), 1196–1203.
Hanafi, N. I., Saidan, N. H., Mohamed, M., Sirajudeen, K. N. S., Gan, S. H., Pahirulzaman, K. A. K., & Visweswara, R. P. (2022). Ischemic heart disease and the potential role of fenugreek (Trigonella foenum graecum Linn.) in cardioprotection. Jurnal Teknologi (Sciences & Engineering), 84(2), 183–197.
Heinisch, O. (1965). De Candolle, A.: Origin of cultivated Plants. 2. Neudruck. Hafner Publishing Comp., New York und London 1964. VIII+ 468 Seiten. Preis $5, 00. Wiley Online Library.
Heshmat?Ghahdarijani, K., Mashayekhiasl, N., Amerizadeh, A., Teimouri Jervekani, Z., & Sadeghi, M. (2020). Effect of fenugreek consumption on serum lipid profile: A systematic review and meta?analysis. Phytotherapy Research, 34(9), 2230–2245. https://doi.org/10.1002/ptr.6670
Hilles, A. R., & Mahmood, S. (2021). Historical background, origin, distribution, and economic importance of fenugreek. In Fenugreek: Biology and applications (pp. 3–11). Springer.
Hozzein, W. N., Saleh, A. M., Habeeb, T. H., Wadaan, M. A. M., & AbdElgawad, H. (2020). CO2 treatment improves the hypocholesterolemic and antioxidant properties of fenugreek seeds. Food Chemistry, 308, 125661. https://doi.org/10.1016/j.foodchem.2019.125661
I??kl?, N. D., & Karababa, E. (2005). Rheological characterization of fenugreek paste (çemen). Journal of Food Engineering, 69(2), 185–190. https://doi.org/10.1016/j.jfoodeng.2004.05.047
Jani, R., Udipi, S. A., & Ghugre, P. S. (2009). Mineral content of complementary foods. The Indian Journal of Pediatrics, 76(1), 37–44. https://doi.org/10.1007/s12098-009-0007-3
Joseph, N. I., Slavin, E., Peppers, B. P., & Hostoffer Jr, R. W. (2018). Fenugreek anaphylaxis in a pediatric patient. Allergy & Rhinology, 9, 2152656718764134. https://doi.org/10.1177/2152656718764134
Kandekar, U., Pujari, R., & Thakurdesai, P. (2022). Applications of Fenugreek in Nutritional and Functional Food Preparations. Fenugreek, 401–436.
Kassaian, N., Azadbakht, L., Forghani, B., & Amini, M. (2009). Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients. International Journal for Vitamin and Nutrition Research, 79(1), 34–39. https://doi.org/10.1024/0300-9831.79.1.34
Khorshidian, N., Yousefi Asli, M., Arab, M., Adeli Mirzaie, A., & Mortazavian, A. M. (2016). Fenugreek: potential applications as a functional food and nutraceutical. Nutrition and Food in Health and Disease, 3(1), 5–16.
Korman, S. H., Cohen, E., & Preminger, A. (2001). Pseudo?maple syrup urine disease due to maternal prenatal ingestion of fenugreek. Journal of Paediatrics and Child Health, 37(4), 403–404. https://doi.org/10.1046/j.1440-1754.2001.00666.x
Kumar, P., Bhandari, U., & Jamadagni, S. (2014). Fenugreek seed extract inhibit fat accumulation and ameliorates dyslipidemia in high fat diet?induced obese rats. BioMed Research International, 2014(1), 606021. https://doi.org/10.1155/2014/606021
Laila, O., & Murtaza, I. (2015). Fenugreek: A treasure of bioactive compounds with promising antidiabetic potential. International Journal of Food and Nutritional Sciences, 4(1), 149–157.
Lal, S. N. D., O’Connor, C. J., & Eyres, L. (2006). Application of emulsifiers/stabilizers in dairy products of high rheology. Advances in Colloid and Interface Science, 123, 433–437.
Lambert, J., & Cormier, J. (2001a). Potential interaction between warfarin and boldo?fenugreek. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 21(4), 509–512.
Lambert, J., & Cormier, J. (2001b). Potential interaction between warfarin and boldo?fenugreek. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 21(4), 509–512. https://doi.org/10.1592/phco.21.5.509.34564
Lamkey, J. W. (2022). Spices, Seasonings, and Flavors—Achieving the Desired Result. Meat and Muscle Biology, 5(3).
Mandal, S., & DebMandal, M. (2016). Fenugreek (Trigonella foenum-graecum L.) oils. In Essential oils in food preservation, flavor and safety (pp. 421–429). Elsevier.
Mathur, P., & Choudhry, M. (2009). Consumption pattern of fenugreek seeds in Rajasthani families. Journal of Human Ecology, 25(1), 9–12.
Mohammadi, R., & Mortazavian, A. M. (2011). Technological aspects of prebiotics in probiotic fermented milks. Food Reviews International, 27(2), 192–212.
Mohammad-Sadeghipour, M., Afsharinasab, M., Mohamadi, M., Mahmoodi, M., Falahati-Pour, S. K., & Hajizadeh, M. R. (2020). The effects of hydro-alcoholic extract of fenugreek seeds on the lipid profile and oxidative stress in fructose-fed rats. Journal of Obesity & Metabolic Syndrome, 29(3), 198. https://doi.org/10.7570/jomes20034
Muraki, E., Chiba, H., Tsunoda, N., & Kasono, K. (2011). Fenugreek improves diet-induced metabolic disorders in rats. Hormone and Metabolic Research, 43(13), 950–955. https://doi.org/10.1055/s-0031-1284358
Naidu, M. M., Shyamala, B. N., Naik, J. P., Sulochanamma, G., & Srinivas, P. (2011). Chemical composition and antioxidant activity of the husk and endosperm of fenugreek seeds. LWT-Food Science and Technology, 44(2), 451–456. https://doi.org/10.1016/j.lwt.2010.08.013
Paramanik, S., Ganguly, A., Rajak, P., & Paramanik, M. (2025). Bioactive Plant?Derived Secondary Metabolites in Non?Communicable Disease Management. Secondary Metabolites and Drug Discovery, 395–418.
Patil, S. P., Niphadkar, P. V, & Bapat, M. M. (1997). Allergy to fenugreek (Trigonella foenum graecum). Annals of Allergy, Asthma & Immunology, 78(3), 297–300. https://doi.org/10.1016/S1081-1206(10)63120-3
Petropoulos, G. A. (2002). Fenugreek: the genus Trigonella. CRC Press.
Rajendram, R., Preedy, V., & Patel, V. (2023). Ancient and Traditional Foods, Plants, Herbs and Spices Used in the Middle East. CRC Press.
Rao, A., & Grant, R. (2020). The effect of Trigonella foenum?graecum extract on prostate?specific antigen, and prostate function in otherwise healthy men with benign prostate hyperplasia. Phytotherapy Research, 34(3), 634–639. https://doi.org/10.1002/ptr.6556
Rastegarpour, M., Hakimi, H., Chamaani, N., Marand, M. J., Zendeboodi, F., Sohrabvandi, S., & Khanniri, E. (2025). Application of various hydrocolloids in fruit-based beverages to improve their properties: A review. International Journal of Biological Macromolecules, 145251.
Ruwali, P., Pandey, N., Jindal, K., & Singh, R. V. (2022). Fenugreek (Trigonella foenum-graecum): Nutraceutical values, phytochemical, ethnomedicinal and pharmacological overview. South African Journal of Botany, 151, 423–431. https://doi.org/10.1016/j.sajb.2022.08.032
Sarkar, P., Dh, L. K., Dhumal, C., Panigrahi, S. S., & Choudhary, R. (2015). Traditional and ayurvedic foods of Indian origin. Journal of Ethnic Foods, 2(3), 97–109. https://doi.org/10.1016/j.jef.2015.08.003
Schauenberg, P., & Paris, F. (1980). Guía de las plantas medicinales. In Guía de las plantas medicinales.
Shabil, M., Bushi, G., Bodige, P. K., Maradi, P. S., Patra, B. P., Padhi, B. K., & Khubchandani, J. (2023). Effect of fenugreek on hyperglycemia: a systematic review and meta-analysis. Medicina, 59(2), 248. https://doi.org/10.3390/medicina59020248
Sharma, R. D. (1986). Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutrition Research, 6(12), 1353–1364.
Singh, U., Chamoli, M., Singh, K. P., Ram, L., Jangir, S., & Maheshwari, R. K. (2022). Amazing health benefit of fenugreek (Trigonella foenum-graecum LINN.). International Journal of Environment and Health Sciences, 4, 19–27.
Stampfli, L., & Nersten, B. (1995). Emulsifiers in bread making. Food Chemistry, 52(4), 353–360.
Tak, Y., Kaur, M., Chitranashi, A., Samota, M. K., Verma, P., Bali, M., & Kumawat, C. (2024). Fenugreek derived diosgenin as an emerging source for diabetic therapy. Frontiers in Nutrition, 11, 1280100. https://doi.org/10.3389/fnut.2024.1280100
Upadhyaya, H. D., Gowda, C. L. L., Buhariwalla, H. K., & Crouch, J. H. (2006). Efficient use of crop germplasm resources: identifying useful germplasm for crop improvement through core and mini-core collections and molecular marker approaches. Plant Genetic Resources, 4(1), 25–35.
Wang, Y., Zheng, Y., Liu, Y., Shan, G., Zhang, B., Cai, Q., Lou, J., & Qu, Y. (2023). The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin. Frontiers in Nutrition, 10, 1149094. https://doi.org/10.3389/fnut.2023.1149094
Yao, D., Zhang, B., Zhu, J., Zhang, Q., Hu, Y., Wang, S., Wang, Y., Cao, H., & Xiao, J. (2020). Advances on application of fenugreek seeds as functional foods: Pharmacology, clinical application, products, patents and market. Critical Reviews in Food Science and Nutrition, 60(14), 2342–2352. https://doi.org/10.1080/10408398.2019.1670552
Zaid, N., Al-Asbahi, A. A. S., & abdu Alhakimi, A. (2024). Genetic diversity of Yemeni Fenugreek (Trigonella foenum-graecum L.) Genotypes. Syrian Journal of Agriculture Research, 16, 575–563. https://agri-research-journal.net/sjar/wp-content/uploads/2024/12/v11n6p49.pdf
Zhang, C., Zhong, X., Bao, S., Urtnasan, M., & Li, M. (2025). Main factors affecting the efficacy of medicinal plants during the cultivation process. Frontiers in Plant Science, 16, 1634926. https://doi.org/10.3389/fpls.2025.1634926
?uk-Go?aszewska, K., & Wierzbowska, J. (2017). Fenugreek: productivity, nutritional value and uses. Journal of Elementology, 22(3).
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