National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Skin and soft tissue infections caused by drug-resistant pathogens represent a growing global health concern, particularly due to the increasing prevalence of antimicrobial resistance (AMR). Among the major causative organisms, Staphylococcus aureus (including methicillin-resistant strains) and Pseudomonas aeruginosa are frequently implicated in chronic and biofilm-associated infections. In this context, plant-derived bioactive compounds offer a promising alternative due to their broad-spectrum antimicrobial, anti-inflammatory, and antibiofilm properties. However, phytochemicals such as Eugenol and Curcumin exhibit poor aqueous solubility, instability, and limited bioavailability, restricting their clinical application. The present study focuses on the development and physicochemical characterization of an oil-in-water Nanoemulsion incorporating selected plant-derived phytochemicals to enhance antimicrobial efficacy against resistant skin pathogens. The integration of phytochemicals into a nanoemulsion-based delivery system is anticipated to enhance solubility, promote effective skin penetration, and improve interaction with microbial membranes, thereby overcoming conventional resistance mechanisms and biofilmassociated tolerance. This research highlights the potential of plant-based Nanoemulsion technology as an innovative and sustainable therapeutic strategy for the management of drugresistant cutaneous infections, offering a promising alternative to conventional antimicrobial therapies.
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