Recent Advances and Challenges in 3D Bioprinting for Tissue Engineering
S. Teresa, M. Flory Shobana*, K. Akash, J. Julit Merlin, S. Reshmi and M. Yugesh
Department of Biotechnology, Hindusthan College of arts and Science (Autonomous), Coimbatore, Tamilnadu, India
*Corresponding author
Abstract:
3D bioprinting is an emerging technology that enables the precise deposition of cells, biomaterials, and bioactive molecules to fabricate functional tissues and organs. Over the last decade, significant advances have been made in bioprinting techniques, bio-ink formulations, and applications in tissue engineering and regenerative medicine. This review summarizes the fundamental principles of 3D bioprinting, compares commonly used printing methods and bio-inks, and highlights their applications in developing engineered tissues and organ models. Key challenges —including vascularization, cell viability, mechanical stability, and clinical translation —are critically discussed. Finally, the review outlines future prospects such as 4D bioprinting, smart biomaterials, and personalized medicine, emphasizing the potential of bioprinting to revolutionize healthcare.
Keywords: 3D bioprinting, bio-inks, tissue engineering, regenerative medicine, biomaterials
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How to cite this article:
Teresa, S., M. Flory Shobana, K. Akash, J. Julit Merlin, S. Reshmi and Yugesh, M. 2026. Recent Advances and Challenges in 3D Bioprinting for Tissue Engineering.
Int.J.Curr.Microbiol.App.Sci. 15(2): 70-83. doi:
https://doi.org/10.20546/ijcmas.2026.1502.007
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National Academy of Agricultural Sciences (NAAS) 
