National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Hepatitis B virus (HBV) remains a major global public health concern, particularly in developing countries. Accurate diagnosis in infected individuals requires virological and biochemical assessments, which are essential for effective management and follow-up. The objective of this study was to evaluate the serum HBV viral load and transaminase levels among patients who tested positive for the HBs antigen in the city of N’Djamena. This was a prospective, cross-sectional analytical study conducted from February 2024 to March 2025 at the Notre Dame of the Apostles Hospital (HNDA) in N’Djamena, Chad. All patients with chronic HBsAg carriage who tested positive and were reconfirmed after six months were included. An information sheet explaining the study objectives was provided to each participant, followed by an informed consent form signed by all who agreed to take part. Of the 171 patients interviewed, 157 were included in the study after signing the consent form, and their information was recorded on the data collection sheet. Transaminase levels were measured using the ABX 400 / Pentra C400 automated chemistry analyzer, and viral loads were quantified using the GeneXpert Cepheid system, an automated molecular biology platform (PCR and real-time RT-PCR). In the study population, 52.2% of participants were male and 47.8% female, with a mean age of 33.14 years (±10.37). A detectable HBV DNA rate of 83% was observed, while ASAT and ALAT levels were normal in 67.5% and 61.8% of patients, respectively. The majority of patients (74.4%) had a viral load below 2000 IU/mL, compared with 24.6% who had a viral load above 2000 IU/mL. Among those with viral loads above 2000 IU/mL, 76% were male and 24% female. This study highlights the evaluation of initial viremia and transaminase profiles among newly diagnosed HBsAg-positive patients.
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