Multidrug-resistant (MDR) bacteria pose a significant global health threat, particularly in hospital settings where they are frequently associated with pus infections. The pathogens commonly implicated include E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. This prospective cross-sectional study was conducted to determine the antibiotic susceptibility of pyogenic bacteria isolated from pus samples to various generations of antibiotics and to assess the incidence of the isolated bacteria. Fifty pus samples were collected over six months at the Surabhi Institute of Medical Sciences, Siddipet. The isolates were identified, and antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method. The study concluded that pyogenic wound infections were prevalent, with K. pneumoniae showing the highest incidence, followed by E. coli, P. aeruginosa, and S. aureus. High resistance was observed in K. pneumoniae and E. coli to beta-lactams, fluoroquinolones, and cotrimoxazole, while S. aureus remained mostly sensitive to linezolid. These findings underscore the critical need for routine surveillance and adherence to guidelines to guide rational antibiotic therapy and curb resistance.

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