National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, with increasing concern due to multidrug resistance (MDR) among uropathogens. This study investigated the diversity and antibiotic resistance profiles of urobacteria isolated from urine samples collected between November 2022 and April 2023 across 70 hospitals in the Nashik district, Maharashtra, India. Of the 541 samples analysed, 482 (89.09%) showed bacterial growth, while 59 (10.90%) exhibited fungal presence. A total of 36 bacterial species were identified, including 24 (66.66%) Gram-negative and 12 (33.33%) Gram-positive strains. Escherichia coli was the predominant pathogen (36.3%), followed by Enterococcus faecalis (9.5%), Klebsiella pneumoniae (7.8%), and multidrug-resistant (MDRO) Pseudomonas aeruginosa (6.2%). MDR analysis revealed that 37.5% of E. coli isolates were resistant to three antibiotic classes, while K. pneumoniae MDRO strains showed extensive resistance, with 69.69% resistant to six classes. Enterococcus faecalis VRE isolates displayed high-level resistance to five and eight antibiotic classes, and Providencia rettgeri showed 75% resistance to seven classes. The study emphasized the alarming spread of MDR in both dominant and rare uropathogens and highlights the need for region-specific antimicrobial stewardship and continuous surveillance to mitigate further escalation of resistance.
Amna, M., Chazan, B., Raz, R., Edelstein, H., & Colodner, R. (2013). Risk factors for non-Escherichia coli community-acquired bacteriuria. Infection, 41(2), 473-477.
Cole, S. J., Records, A. R., Orr, M. W., Linden, S. B., & Lee, V. T. (2014). Catheter-associated urinary tract infection by Pseudomonas aeruginosa is mediated by exopolysaccharide-independent biofilms. Infection and immunity, 82(5), 2048-2058.
Kumar, M. S., & Das, A. P. (2016). Molecular identification of multi drug resistant bacteria from urinary tract infected urine samples. Microb Pathog, 98, 37-44. https://doi.org/10.1016/j.micpath.2016.06.029
Kumar, M., & Das, A. (2016). Molecular identification of multi drug resistant bacteria from urinary tract infected urine samples. Microbial pathogenesis, 98, 37-44.
Odsbu, I., Khedkar, S., Khedkar, U., Nerkar, S. S., Tamhankar, A. J., & Stålsby Lundborg, C. (2018). High proportions of multidrug-resistant Acinetobacter spp. isolates in a district in Western India: a four-year antibiotic susceptibility study of clinical isolates. International journal of environmental research and public health, 15(1), 153.
Porter, G., Kotwani, A., Bhullar, L., & Joshi, J. (2021). Over-the-counter sales of antibiotics for human use in India: The challenges and opportunities for regulation. Medical Law International, 21(2), 147-173. https://doi.org/10.1177/09685332211020786
Rodrigues, W. F., Miguel, C. B., Nogueira, A. P. O., Ueira-Vieira, C., Paulino, T. D. P., Soares, S. D. C., De Resende, E. A. M. R., Lazo-Chica, J. E., Araújo, M. C., & Oliveira, C. J. (2016). Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study. International Journal of Environmental Research and Public Health, 13(9), 918. https://www.mdpi.com/1660-4601/13/9/918
Shackley, D. C., Whytock, C., Parry, G., Clarke, L., Vincent, C., Harrison, A., John, A., Provost, L., & Power, M. (2017). Variation in the prevalence of urinary catheters: a profile of National Health Service patients in England. BMJ open, 7(6), e013842.
Shetty, N., Hill, G., & Ridgway, G. (1998). The Vitek analyser for routine bacterial identification and susceptibility testing: protocols, problems, and pitfalls. Journal of clinical pathology, 51(4), 316-323.
Shetty, N., Hill, G., & Ridgway, G. L. (1998). The Vitek analyser for routine bacterial identification and susceptibility testing: protocols, problems, and pitfalls. J Clin Pathol, 51(4), 316-323. https://doi.org/10.1136/jcp.51.4.316
Silva, A., Costa, E., Freitas, A., & Almeida, A. (2022). Revisiting the frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections. Antibiotics, 11(6), 768.
Sun, D., Jeannot, K., Xiao, Y., & Knapp, C. W. (2019). Horizontal gene transfer mediated bacterial antibiotic resistance. In (Vol. 10, pp. 1933): Frontiers Media SA.
Torres-Sangiao, E., Lamas Rodriguez, B., Cea Pájaro, M., Carracedo Montero, R., Parajó Pazos, N., & García-Riestra, C. (2022). Direct Urine Resistance Detection Using VITEK 2. Antibiotics (Basel), 11(5). https://doi.org/10.3390/antibiotics11050663
Citations |
 |
 |
 |
 |
