National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study presents novel anionic bicelles—nanoparticles composed of DPPG and paclitaxel stabilized by cholic acid-based surfactants—prepared via a low-temperature (4°C) ultrasonic fragmentation process, yielding uniform 12-nm particles. These bicelles effectively penetrated the stratum corneum (intercellular spaces ~100 nm) and infiltrated the epidermis in vitro, demonstrating potent anti-skin cancer activity against A431, SCL I, and KB cells. In vivo, topical application significantly reduced papilloma formation in a murine skin cancer model, whereas free paclitaxel exacerbated tumor growth, confirming enhanced efficacy and targeted delivery. Concurrently, glycosylated memantine derivatives (memary-gluco-oligosaccharides) were enzymatically synthesized and exhibited superior neuroprotective effects: enhancing survival of TH? neurons in rat midbrain cultures and protecting hippocampal neurons against Aβ toxicity. In vivo, these conjugates crossed the blood-brain barrier following intraperitoneal or oral administration, increasing synaptic density in the dentate gyrus and improving spatial learning. In 6-OHDA-induced hemiparkinsonian mice, memary-gluco-oligosaccharides reduced ipsilateral rotations and restored contralateral hindlimb stepping, indicating marked motor symptom amelioration. Furthermore, α-tocopherol glucoside demonstrated potent anti-allergic activity against wheat allergens (gliadin/glutenin), while daidzein and glycitein glucosides effectively suppressed soybean allergen (globulin)-induced responses. Collectively, these findings establish that lipid-based nanocarriers enable transdermal drug delivery for skin cancer therapy, while enzymatic glycosylation enhances bioavailability, neuroprotection, and anti-allergic efficacy—offering promising platforms for treating neurological disorders and allergic conditions.
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