Spectrum of Microorganisms Causing Infections in Post Renal Transplant Patients in a Tertiary Care Hospital, Calicut
1Department of Microbiology, MIMS College of Allied Health Sciences, Malappuram, Kerala University of Health Sciences, India 2Department of Microbiology, Aster MIMS Hospital, Calicut, India
*Corresponding author
Abstract:
Renal transplant recipients are particularly susceptible to a wide range of infections due to their immunosuppressive therapy, with urinary tract infections (UTIs) being the most prevalent. The microbial spectrum commonly includes Gram-negative bacteria such as Escherichia coli, Klebsiella spp., and Pseudomonas sps, as well as Gram-positive organisms like Enterococcus spp. Fungal pathogens, notably Candida spp also contribute significantly to the infectious burden in this population. The emergence of multidrug-resistant organisms (MDROs) has further complicated treatment strategies, underscoring the need for vigilant surveillance and tailored antimicrobial therapy. Identification of post renal transplant infections is a key elements of a thorough infection prevention and control strategy in healthcare environments. To determine the microbial infections, to isolate and identify microorganisms causing infections among post renal transplant patients. Also to study the antimicrobial susceptibility pattern and Multidrug resistant organisms (MDRO’S) in post renal transplant patients. Clinical samples, including urine, blood, exudates, and body fluids, are analyzed using standard bacteriological methods to identify causative pathogens. Antimicrobial susceptibility testing is performed via modified Kirby-Bauer disc diffusion, with results interpreted according to CLSI guidelines. Additionally, the VITEK 2 Compact system is used for testing non-fermenting Gram-negative bacteria, anaerobes, and fungi. Blood and body fluids are processed using the BacT/ALERT 3D system. Total 193 Renal transplants took place during this period. Out of which, 39 had post renal transplant infections (20. 2%). Among 39 infected patients 28 (71. 79%) patients had infections in 1st month of transplantation followed by 11 (28. 21%) patients had infection in the 2nd month. A total 48 organisms were isolated from 39 culture positive cases. Klebsiella spp, Enterococcus spp., and E. coli were the most frequently isolated organisms. The more prevalent microbial infection was UTI. Out of 48 organisms 11 were MDRO’S (21. 91%). This study identifies post renal transplant infections, emphasizing the importance of accurate detection for effective treatment. By acknowledging the diverse range of pathogens and talking a proactive approach health care providers can optimize care for kidney transplant patients and minimize the risk of infections and also this would be helpful for hospital infection control team to reduce the incidence of infections among renal transplant patients.
Keywords: Post renal transplant infections, Microorganisms, Multidrug resistant organisms
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How to cite this article:
Anjali M. P., M.Savitha, M. Swathy Viswanath, Reshmi Gopalakrishnan, M. M. Athulya, Gayathri Meyana, Irfana and Vismaya P. P. 2025. Spectrum of Microorganisms Causing Infections in Post Renal Transplant Patients in a Tertiary Care Hospital, Calicut.
Int.J.Curr.Microbiol.App.Sci. 14(11): 37-54. doi:
https://doi.org/10.20546/ijcmas.2025.1411.005
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National Academy of Agricultural Sciences (NAAS) 
