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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2023: 95.56
Index Copernicus ICI Journals Master List 2023 - IJCMAS--ICV 2023: 95.56
For more details click here
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Original Research Articles                      Volume : 14, Issue:10, October, 2025
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
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Int.J.Curr.Microbiol.App.Sci.2025.14(10): 261-270
DOI: https://doi.org/10.20546/ijcmas.2025.1410.027


Evaluation of FineX 3060 Supplementation on Immune Modulation, Tissue Distribution, and Pharmacokinetics
Shriniwas Sawant*, Parth Sutar and Akshay Wankhade
Fine Organic Industries Limited, Mahatma Gandhi Road, Rajawadi Colony,Ghatkopar East, Mumbai, Maharashtra 400077, India
*Corresponding author
Abstract:

The poultry industry faces increasing pressure to reduce antibiotic use while maintaining optimal growth performance and disease resistance. Medium-chain fatty acids, particularly lauric acid, have emerged as promising alternatives to conventional growth promoters. This study investigated the dose-dependent effects of dietary lauric acid supplementation on immune cell populations and tissue distribution in broiler chickens. A total of five experimental groups were established, including a control group receiving a standard diet and four treatment groups supplemented with lauric acid at 375, 500, 750, and 1000 g/MT feed. Flow cytometric analysis revealed significant dose-dependent increases in B lymphocyte populations (Bu1+ cells), with the 750 g/MT group showing maximum enhancement (28.82 ± 1.03%) compared to control (20.73 ± 0.52%). Pharmacokinetic analysis demonstrated sustained plasma lauric acid concentrations over 48 hours, with dose-proportional increases across treatment groups. Tissue distribution studies showed preferential accumulation in respiratory tissues, with lung and trachea concentrations reaching 8.98 ± 0.21 ?g/ml and 6.45 ± 0.25 ?g/ml respectively in the highest dose group. These findings suggest that dietary lauric acid supplementation at 750 g/MT provides optimal immunomodulatory effects in broiler chickens, supporting its potential as a natural feed additive for enhancing immune function and respiratory health.


Keywords: Lauric acid, broiler chickens, immune modulation, B lymphocytes, pharmacokinetics, tissue distribution

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How to cite this article:

Shriniwas Sawant, Parth Sutar and Akshay Wankhade. 2025. Evaluation of FineX 3060 Supplementation on Immune Modulation, Tissue Distribution, and Pharmacokinetics.Int.J.Curr.Microbiol.App.Sci. 14(10): 261-270. doi: https://doi.org/10.20546/ijcmas.2025.1410.027
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