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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 14, Issue:10, October, 2025

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2025.14(10): 234-238
DOI: https://doi.org/10.20546/ijcmas.2025.1410.023


Invasive Haemophilus influenzae Infection in Immunocompromised Child
1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India 2Department. of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
*Corresponding author
Abstract:

The gram-negative, capnophilic coccobacillus Haemophilus influenzae is a member of the Pasteurellaceae family. It can result in otitis media as well as serious invasive illnesses. Based on capsular antigens, H. influenzae strains can be categorized as typeable or non-typeableWe present a case of H.influenzae sepsis in 2 years old child with Acute Lymphoblastic Leukemia who was completely vaccinated for age. Patient presented with cough, cold and breathlessness. On respiratory system examination, bilateral diffuse crepitations was heard, subcostal and suprasternal retractions were seen. Blood culture bottle grew Hemophilus influenzae. The patient clinically improved with cefoperazone - sulbactam and repeat cultures sent were sterile. Non type-b strain or wanning immunity of H.influenzae type b(Hib) conjugate vaccine in immunocompromised state could be attributed to H.influenzae sepsis in this patient. Appropriate antimicrobial therapy is essential to reduce mortality and morbiditity. To prevent invasive disease, non-type b strains might need to be included in the Hib conjugate vaccination. Additionally, giving leukemia patients a booster dose of the Hib conjugate vaccination helps to prevent the invasive disease.


Keywords: Haemophilus influenza, gram-negative, Leukemia, Acute Lymphoblastic


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How to cite this article:

Benedict Vinothini,A., K.Sultan Basha, K.P.V. Hyma, Aravindh Selladurai, Jaikumar Govindaswamy Ramamoorthy and Apurba S. Sastry. 2025. Invasive Haemophilus influenzae Infection in Immunocompromised Child.Int.J.Curr.Microbiol.App.Sci. 14(10): 234-238. doi: https://doi.org/10.20546/ijcmas.2025.1410.023
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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