Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2023 - IJCMAS--ICV 2023: 95.56 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020] For more details click here

Login as a Reviewer


See Guidelines to Authors
Current Issues
Download Publication Certificate

Original Research Articles                      Volume : 14, Issue:10, October, 2025

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2025.14(10): 126-132
DOI: https://doi.org/10.20546/ijcmas.2025.1410.011


Comparative Evaluation of Antimicrobial Efficacy of Multipurpose Topical Creams
Agnes Kharat1* and Vaishali Sonawane2
1Department of Zoology, MGV’s Loknete Vyankatrao Hiray Arts, Science & Commerce College (Autonomous), Nashik, India 2Department of Microbiology, MVP’s K.A.A.N.M. Sonawane Arts, Science and Commerce College, Satana, SPPU, Pune, India
*Corresponding author
Abstract:

SSTIs are a major international health problem, which is becoming increasingly complex due to antimicrobial resistance (AMR) and the popularity of unproven over-the-counter creams. The antimicrobial effectiveness of four commercially available topical formulations namely Soframycin (pharmaceutical antibiotic), Colgate Dental Cream (multipurpose formulation), Boroplus (herbal preparation), and Fair and Lovely (cosmetic cream) were systematically tested against S. aureus, B. subtilis, E. coli and A. niger in agar well diffusion method. Findings indicated a strong pecking order: Soframycin was the strongest antimicrobial agent against all organisms, Colgate had medium effect, Boroplus had weak effects and Fair and Lovely showed no effect at all. The results of these findings point to some essential inconsistencies between clinically-proven drugs and consumer-centered products with the tendency of being assertive by antimicrobial claims. It is clear, in the absence of activity in cosmetic cream and limited efficacy of herbal preparations, the dangers in replacing unverified products with evidence-based therapies with potential implications of failure to cure and resistance development. This paper offers experimental data to support the significance of rational topical therapy, regulatory examination of consumer products, and educating the populace to reverse unsuitable culture during the AMR era.


Keywords: Antimicrobial resistance, rational therapy, skin infections, herbal formulations, consumer product


References:

Silverberg, B. (2021). A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting. Clinics and Practice, 11(1), 65–74. https://doi.org/10.3390/clinpract11010011

Chiller, K., Selkin, B. A., & Murakawa, G. J. (2001). Skin Microflora and Bacterial Infections of the Skin. Journal of Investigative Dermatology Symposium Proceedings6(3), 170–174. https://doi.org/10.1046/j.0022-202x.2001.00043.x

Salam, M. A., Al-Amin, M. Y., Salam, M. T., Pawar, J. S., Akhter, N., Rabaan, A. A., & Alqumber, M. A. A. (2023). Antimicrobial Resistance: a Growing Serious Threat for Global Public Health. Healthcare11(13). https://doi.org/10.3390/healthcare11131946

Noa Ziklo, Bibi, M., Sinai, L., & Salama, P. (2024). Niacinamide Antimicrobial Efficacy and Its Mode of Action via Microbial Cell Cycle Arrest. Microorganisms12(8), 1581–1581. https://doi.org/10.3390/microorganisms12081581

Ramirez, M., & Tolmasky, M. (2017). Amikacin: Uses, Resistance, and Prospects for Inhibition. Molecules22(12), 2267. https://doi.org/10.3390/molecules22122267

Argenziano, G., Ardigò, M., Micali, G., Nasca, M. R., Scilletta, A., Tognetti, L., Pietro Rubegni, & Veraldi, S. (2024). Review - Expert Opinion on Antibiotics and Antibiotic Resistance in Dermatology. Dermatology Practical & Conceptual14(4), e2024282–e2024282. https://doi.org/10.5826/dpc.1404a282

Lang, J. C., Shahata, M., & Melican, K. (2024). Towards Sustainable Antimicrobial Therapies for Staphylococcus aureus Skin Infections. Deleted Journal1(1). https://doi.org/10.1093/sumbio/qvae023

Muhaj, F. F., George, S. J., & Tyring, S. K. (2022). Bacterial antimicrobial resistance and dermatological ramifications*. British Journal of Dermatology187(1), 12–20. https://doi.org/10.1111/bjd.21033

Kulik-Siarek, K., Klimek-Szczykutowicz, M., B?o?ska-Sikora, E., Zarembska, E., & Wrzosek, M. (2024). Exploring the Antimicrobial Potential of Natural Substances and Their Applications in Cosmetic Formulations. Cosmetics12(1), 1.https://doi.org/10.3390/cosmetics12010001

Strompfová, V., Štempelová, L., & Tomáš Wolaschka. (2024). Antibacterial activity of plant-derived compounds and cream formulations against canine skin bacteria. Veterinary Research Communications. https://doi.org/10.1007/s11259-024-10324-0

Tirant, M., Tirant, H., & Uwe Wollina. (2024). Herbal Bioactive Compounds for Skin Infections and Inflammatory Conditions. Open Access Macedonian Journal of Medical Sciences12, 1–44. https://doi.org/10.3889/oamjms.2024.11888

Agrawal, R., Priyanka Jurel, Deshmukh, R., Ranjit Kumar Harwansh, Garg, A., Kumar, A., Singh, S., Ajay Guru, Kumar, A., & Vinoth Kumarasamy. (2024). Emerging Trends in the Treatment of Skin Disorders by Herbal Drugs: Traditional and Nanotechnological Approach. Pharmaceutics16(7), 869–869. https://doi.org/10.3390/pharmaceutics16070869

Srivastav, A., Srivastav, Y., Hameed, A., & Ahmad, M. I. (2024). Prevention and cure of dermatology disorders using herbal medications: summary. International Journal of Indigenous Herbs and Drugs, 1–14. https://doi.org/10.46956/ijihd.v9i1.568

Shehara Gunawardana, & Dias, B. (2024). Methodological advances in formulation and assay of herbal resources-based topical drug delivery systems. Journal of Complementary and Integrative Medicinehttps://doi.org/10.1515/jcim-2024-0181

Anita Ioana Visan, & Negut, I. (2024). Coatings Based on Essential Oils for Combating Antibiotic Resistance. Antibiotics13(7), 625–625. https://doi.org/10.3390/antibiotics13070625

Kamat, S., Marathe, P., Tripathi, R., Raut, S., & Khatri, N. (2020). Over-the-counter medicines: Global perspective and Indian scenario. Journal of Postgraduate Medicine66(1), 28. https://doi.org/10.4103/jpgm.jpgm_381_19

Ayukekbong, J. A., Ntemgwa, M., & Atabe, A. N. (2017). The threat of antimicrobial resistance in developing countries: causes and control strategies. Antimicrobial Resistance & Infection Control6(1). https://doi.org/10.1186/s13756-017-0208-x

Conover, E. A. (2002). Over-the-Counter Products: Nonprescription Medications, Nutraceuticals, and Herbal Agents.cClinical Obstetrics and Gynecology, 45(1), 89–98. https://doi.org/10.1097/00003081-200203000-00010

Bouissane, L., Elfardi, Y., Khatib, S., … et al. (2025). Medicinal plants and their derivatives for skin and hair: A Mediterranean perspective of women care. Archives of Dermatological Research, 317, 710. https://doi.org/10.1007/s00403-025-04202-1

Download this article as Download

How to cite this article:

Agnes Kharat and Vaishali Sonawane. 2025. Comparative Evaluation of Antimicrobial Efficacy of Multipurpose Topical Creams.Int.J.Curr.Microbiol.App.Sci. 14(10): 126-132. doi: https://doi.org/10.20546/ijcmas.2025.1410.011
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

Citations