National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Urinary tract infections (UTIs) are a major public health concern, with Escherichia coli being the predominant uropathogen. The increasing emergence of multidrug-resistant (MDR) strains, particularly those producing extended-spectrum β-lactamases (ESBLs), complicates treatment strategies. This study aimed to detect and characterize ESBL genotypes among MDR uropathogenic E. coli isolated from clinical urine samples. Phenotypic confirmation of ESBL production was performed using standard disc diffusion methods, and molecular analysis was conducted to identify the presence of key ESBL genes, including bla<sub>TEM</sub>, bla<sub>SHV</sub>, and bla<sub>CTX-M</sub>. A high prevalence of ESBL producers was observed, with bla<sub>CTX-M</sub> being the most common genotype detected. The isolates exhibited resistance to multiple antibiotic classes, while showing susceptibility to carbapenems. The findings highlight the urgent need for molecular surveillance and antibiotic stewardship to curb the spread of ESBL-producing uropathogens in clinical settings.
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