National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Alphonsea sclerocarpa Thwaites, a member of the family Annonaceae, is a genus widely distributed across tropical regions. Traditionally, the whole plant of A. sclerocarpa has been valued for its significant therapeutic properties. The present study involved GC-MS analysis of plant extracts prepared using two different solvents: ethanol and petroleum ether. The ethanol extract identified 25 compounds, whereas the petroleum ether extract revealed 24 compounds. From each extract, four compounds were shortlisted for molecular docking studies against the target protein 6OVA.The binding energies of the ethanol-derived compounds were -1.8, -3.8, -1.9, and -1.5 kcal/mol, respectively. In contrast, the petroleum ether-derived compounds exhibited binding affinities of -1.1, -0.8, -1.6, and -2.0 kcal/mol. These results suggest that the compounds obtained from the ethanol extract have comparatively stronger binding affinities than those from the petroleum ether extract.
Ayesha Khanum, Yamin Bibi, IIham Khan, Ghazala Mustafa, Kotb A. Attia, Arif Ahmed Mohammed, Seung Huwan Yang & Abdul Qayyum (2024) Molecular docking of bioactive compounds extracted and purified from selected medicinal Plant Species against COVID-19 proteins &in vitro evaluation. Scientific reports. https://doi.org/10.1038/S41598-024-54470-6.
Md.Tarikul Islam, Md.Aktaruzzaman, Ahmed Saif, Ayesha Akter, Mashooq Ahmad Bhat, Mirza Mahfuj Hossain, S. M. Nur Alam, Rifat Rayhan, Saira Rehman, Muhammad Yaseen, Md. Obayed Raihan (2025). In Silico-based Identification of Natural Inhibitors from Traditionally Used Medicinal Plants that can Inhibit Dengue Infection. Molecular Biotechnology. Vol:67; 2382-2398. https://doi.org/10.1007/S12033-024-01204-8.
Petrovska BB (2012) Historical review of medicinal plants usage. Pharmacogn Rev 6(11):1–5. https://doi.org/10.4103/0973-7847.95849.
Prasad DN (2009) Antioxidant activity of Alphonsea sclerocarpa bark. Res J Pharmacol Pharmacodynamics 1(2):66–69.
Pratistha Singh, Vinay Kumar Singh, Anil Kumar Singh(2019). Molecular docking analysis of Candidate Compounds derived from medicinal plants with type 2 diabetes mellitus targets. Bioinformation Vol 15:3.
Soumya Khare, Tanushree Chatterjee, Shailendra Gupta, and Ashish Patel (2023). Analysing Phytocompounds, Antioxidants, and In-Silico Molecular Docking of Plant-Derived Potential Andrographis Paniculata Inhibitory Action to Managed Beta Thalassemia. Medinformatics. Vol:1(3) 122-130. https://doi.org/10.47852/bonviewMEDIN42021979
Suman Joshi DSD, Venkata Rao G, Satya Prasad M, Kishore Babu M, Surya Narayana S, Krishna Satya A (2017) Phytochemical screening and evaluation of antioxidant, antibacterial, and antifungal activity of medicinal plant Alphonsea sclerocarpa Thaw. J Pharmacogn Phytochem 6(4):1280–1286.
Tacic D, Wannigama GP, Cassels BK, Cave A (1987) Alkaloids of Alphonsea sclerocarpa. J Nat Prod 50(3):518–519. http://dx.doi.org/10.1021/np50051a036
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