National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Klebsiella species are opportunistic pathogens responsible for a wide range of hospital and community-acquired infections, including pneumonia, urinary tract infections, septicemia, and liver abscesses. The global emergence of multidrug-resistant (MDR) Klebsiella, particularly those producing extended-spectrum β-lactamases (ESBLs), poses a significant public health challenge. ESBLs hydrolyze β-lactam antibiotics, rendering extended-spectrum cephalosporins and monobactams ineffective. The widespread use and misuse of antibiotics in human medicine and agriculture have accelerated the development and dissemination of resistance, facilitated by horizontal gene transfer through plasmids, transposons, and integrons. Among ESBLs, TEM, SHV, and CTX-M types are most prevalent, with CTX-M-15 emerging as a dominant variant, especially in Asia, including India. Klebsiella species are the primary reservoirs of ESBL genes and are frequently implicated in nosocomial outbreaks. Accurate detection and molecular characterization of these strains are essential for epidemiological surveillance and outbreak control. Molecular typing techniques such as SDS-PAGE and RAPD are valuable tools for studying clonal relationships and resistance gene dissemination. Despite the high prevalence of ESBL-producing Klebsiella in India, limited data exist for regions of Maharashtra. This study was undertaken to determine the phenotypic prevalence and molecular epidemiology of ESBL-producing Klebsiella species in these regions, establishing a baseline for resistance surveillance and control strategies.
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