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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 14, Issue:7, July, 2025

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2025.14(7): 156-161
DOI: https://doi.org/10.20546/ijcmas.2025.1407.019


Understanding Human Metapneumovirus (HMPV): Transmission, Diagnosis, and Management
Shyamala Ravikoti1, Seykkulandai Kuppuswamy Mohanasundari2* and Mamta Choudhary3
1Department of Microbiology, AIIMS Bibinagar, Hyderabad, India
2Department of Nursing, AIIMS Bibinagar, Hyderabad, India
3Department of Nursing, AIIMS New Delhi, India
*Corresponding author
Abstract:

Human Metapneumovirus (HMPV) is a significant respiratory virus that predominantly impacts infants, young children, the elderly, and individuals with compromised immune systems. First identified in 2001, HMPV is closely related to avian metapneumovirus and ranks among the leading causes of respiratory infections globally, particularly during the winter and early spring seasons. In 2024, northern China experienced a surge in HMPV cases, with the first confirmed cases reported in India in early 2025. The virus presents symptoms similar to other respiratory infections, such as COVID-19 and RSV, but can cause severe complications, including pneumonia, bronchiolitis, and respiratory failure in high-risk groups. HMPV possesses a single-stranded, negative-sense RNA genome and displays genetic diversity, classified into two primary subgroups, A and B. Diagnosis is typically confirmed through RT-PCR, and treatment primarily involves supportive care, including oxygen therapy, hydration, and symptom management. This review synthesizes evidence from published articles indexed in Medline, CINAHL, Social Sciences Citation Index, PsychINFO, selected journals since 2001, and reference lists. It aims to provide a comprehensive overview of HMPV, emphasizing the importance of increased awareness and the urgent need for research into preventive and therapeutic measures. The goal is to raise awareness about HMPV in the context of co-circulating respiratory viruses and to emphasize its clinical significance.


Keywords: Human Metapneumovirus (HMPV), Respiratory infection, Pulmonary infection, Emerging infection and immuno-compromised


References:

Aljazeera, What is HMPV, the respiratory virus surging in China? [Online 8 Jan 2025] 

CDC. Human Metapneumovirus. [Accessed on Jan 9 2024]. Available form: https://www.cdc.gov/human-metapneumovirus/about/index.html

Choudhary M, Gopichandran L, Jyotishana KP. Covid-19-related anxiety and coping strategies among nursing professionals working in COVID intensive care unit: A cross-sectional survey. Indian J Psychiatr Nurs. 2022;19(2):104–8. https://doi.org/10.4103/iopn.iopn_71_21

Choudhary M, Gopichandran L. Post Covid-19 Complications: A New Dimension of Awareness for Healthcare Workers. Asian J Nurs Educ Res. 2021;11(4):455-458. https://doi.org/10.52711/2349-2996.2021.00110.

Cleveland Clinic. Human metapneumovirus [Updated on June 20 2023] 

Embarek Mohamed MS, Reiche J, Jacobsen S, Thabit AG, Badary MS, Brune W, Schweiger B, Osmann AH. Molecular analysis of human metapneumovirus detected in patients with lower respiratory tract infection in upper egypt. Int J Microbiol. 2014;2014:290793. https://doi.org/10.1155/2014/290793

Febbo JN, Emerging Pulmonary Infections in Clinical Practice. Advances in Clinical Radiology 3: Advances in clinical Radiology-3; 202; 103–124 https://doi.org/10.1016/j.yacr.2021.04.010 

Jesse ST, Ludlow M, Osterhaus ADME. Zoonotic origins of human metapneumovirus: A journey from birds to humans. Viruses. 2022 Mar 25;14(4):677. https://doi.org/10.3390/v14040677

Kahn JS. Epidemiology of human metapneumovirus. Clin Microbiol Rev. 2006 Jul;19(3):546-57. https://doi.org/10.1128/CMR.00014-06. PMID: 16847085; PMCID: PMC1539100.

Kamau, E., Oketch, J.W., de Laurent, Z.R. et al., Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia. BMC Genomics 21, 5 (2020). https://doi.org/10.1186/s12864-019-6400-z

Mazzoncini JP Jr, Crowell CB, Kang CS. Human metapneumovirus: an emerging respiratory pathogen. J Emerg Med. 2010 May;38(4):456-9. https://doi.org/10.1016/j.jemermed.2007.11.051

Papenburg J, Hamelin MÈ, Ouhoummane N, Carbonneau J, Ouakki M, Raymond F, Robitaille L, Corbeil J, Caouette G, Frenette L, De Serres G, Boivin G. Comparison of risk factors for human metapneumovirus and respiratory syncytial virus disease severity in young children. J Infect Dis. 2012 Jul 15;206(2):178-89. https://doi.org/10.1093/infdis/jis333

Times of India. HMPV in India, new cases identified: All about symptoms, treatment and how to remain safe. [Internet]. 2025 Jan 9 [cited 2025 Jan 9]. 

Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001 Jun;7(6):719-24. https://doi.org/10.1038/89098

Wang X, Libster R, et al., Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study. Lancet Glob Health. 2021;9(1):e33-e43. https://doi.org/10.1016/s2214-109x(20)30393-4

Yang CF, Wang CK, Tollefson SJ, Piyaratna R, Lintao LD, Chu M, Liem A, Mark M, Spaete RR, Crowe JE Jr, Williams JV. Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years. Virol J. 2009 Sep 9;6:138. https://doi.org/10.1186/1743-422X-6-138


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How to cite this article:

Shyamala Ravikoti, Seykkulandai kuppuswamy Mohanasundari and Mamta Choudhary. 2025. Understanding Human Metapneumovirus (HMPV): Transmission, Diagnosis, and Management.Int.J.Curr.Microbiol.App.Sci. 14(7): 156-161. doi: https://doi.org/10.20546/ijcmas.2025.1407.019
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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