National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
A series of twenty two novel piperazine derivatives were screened for their antimicrobial activities by disc diffusion method and micro dilution method against the ATCC strains of certain selected Gram- positive (MRSA, Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Citrobacter, Shigella flexineri, Pseudomonas aeruginosa) with the standard drugs amongst the synthesized novel compounds RL-308, RL-327and RL-328 showed potent anti bactericidal activities. Hence, they were subjected to higher assays with different concentrations and were compared to the respective standard drugs. Then Minimum inhibitory concentration (MIC) assay, Minimum bactericidal concentration (MBC) assay were performed to those three compounds. Minimum concentration of RL-308 was analyzed by using MIC assay which displayed a potent results against Shigella flexineri, S.aureus, MRSA & Shigella dysentriae at the concentration of 2ug, 4ug, 16ug &128 ug concentration. It proved to be very effective against Shigella flexineri at the concentration of 2ug. Where in RL-328 showed MIC at the concentration of 128ug. The MBC of the compound RL-308 was estimated to be 4ug, 8ug, 32ug against the same pathogenic bacterial strains. Hence, the piperazine compound RL-308 proved to be very effective antibacterial activity against human pathogens and can be used as an effective antibacterial agent to cure diseases caused by Shigella flexineri, S. aureus, Methicillin resistant S. aureus & Shigella dysentriae.
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