National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Technol PG-resveratrol or paclitaxel glucoside nanoparticles were successfully prepared by dispersing Technol PG powder with cholic acid-based surfactants such as SC. Composite nanoparticles composed of an anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and resveratrol or paclitaxel were successfully prepared by mixing them in water followed by a subsequent heating and cooling process. Upon addition of small-sized fluorescently labeled resveratrol nanoparticles with DPPG to rat skin tissue, fluorescently labeled resveratrol molecules permeated to the stratum corneum (in vitro). DPPG-paclitaxel nanoparticles exerted high anti-skin cancer activity (in vitro). Technol PG-paclitaxel glucoside nanoparticles also showed high anti-skin cancer activity (in vitro). During the anti-cancer test using mouse model of skin cancer, this study revealed that the numbers of papillomas of the mouse treated with paclitaxel glucoside nanoparticles stabilized with Technol PG were decreased, although those of the mouse treated with paclitaxel glucoside itself were increased. Thus, our study established that since paclitaxel glucoside nanoparticles stabilized with Technol PG could permeate stratum corneum and be incorporated into the epidermis layer of mouse, they could also treat skin cancer (in vivo). This study showed that since DPPG-resveratrol nanoparticles could permeate stratum corneum and be incorporated into the epidermis layer of mouse, they could also treat atopic dermatitis.
Carlucci, C. D., Hui, Y., Chumanevich, A. P., et al., 2023. Resveratrol protects against skin inflammation through inhibition of mast cell, sphingosine kinase-1, stat3 and NF-B p65 signaling activation in mice. Int. J. Mol. Sci. 24:1-14. https://doi.org/10.3390/ijms24076707
Chiocchetti, R., Salamanca, G., Silva, M. D., et al., 2022. Cannabinoid receptors in the inflammatory cells of canine atopic dermatitis. Front. Veter. Sci. 9:1-22. https://doi.org/10.3389/fvets.2022.987132
Gelmon, K. 1994. The taxoids: paclitaxel and docetaxel. Lancet. 344:1267-1272. https://doi.org/10.1016/s0140-6736(94)90754-4
Ishida, S., Kato, K., Tanaka, M., Odamaki, T., Kubo, R., Mitsuyama, E., Xiao, J.Z., Yamaguchi, R., Uematsu, S., Imoto, S., et al. (2020). Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. Commun. Biol. 3, 686. https://doi.org/10.1038/s42003-020-01416-z.
Luo, C. and Shen, J. 2017. Research progress in advanced melanoma. Cancer Lett. 397:120-126. https://doi.org/10.1016/j.canlet.2017.03.037
Narayanan, D. L., Saladi, R. N. and Fox, J. L. 2010. Review: ultraviolet radiation and skin cancer. Int J Dermatol. 49:978-986. https://doi.org/10.1111/j.1365-4632.2010.04474.x.
Perez, E. A. 2009. Microtubule inhibitors: differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Mol. Cancer Ther. 8:2086-2095. https://doi.org/10.1158/1535-7163.MCT-09-0366
Uchida, N., Shimoda, K. and Hamada, H. 2022a. Dispersion of cannabidiol into small-sized nanoparticles using Technol PG. Nat. Prod. Commun. 17:1-3. https://doi.org/10.1177/1934578X221130864
Uchida, N., Yanagi, M. and Hamada, H. 2022b. Anionic technol PG-based nanoparticles prepared using cholic acid-derived surfactants. Nat. Prod. Commun. 17:1-3. https://doi.org/10.1177/1934578X221098844
Uchida, N., Yanagi, M., Shimoda, K. and Hamada, H. 2020. Transdermal delivery of small-sized resveratrol nanoparticles to epidermis using anionic phospholipids. Nat. Prod. Commun. 15:1-5. https://doi.org/10.1177/1934578X20951443
Yanagi, M., Uchida, N. and Hamada, H. 2019. Versatile synthetic route for resveratrol modification via amine functionalization. Nat. Prod. Commun. 15:1-3. https://doi.org/10.1177/1934578X19876210
Zhu, L. and Chen, L. 2019. Progress in research on paclitaxel and tumor immunotherapy. Cellular & Molecular Biology Letters 24:1-11. https://doi.org/10.1186/s11658-019-0164-y
Citations |
 |
 |
 |
 |
