National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The β-lactamase enzymes produced by Staphylococcus aureus confer resistance against β-lactam antibiotics like penicillin; and are encoded in the blaZ gene located on a transposable part of the large plasmid within the bacterial cells. Clover Leaf Method was performed on all penicillin resistant Staphylococcus aureus isolates to confirm the Beta lactamase production. This is an important confirmatory method to detect the production of beta-lactamase enzyme. Results : Out of 76 isolates 92%(70) were found to be the producers of Beta lactamase enzyme which are resistant to penicillin and 08% (6) didn’t show cloverleaf pattern which are sensitive to penicillin. Out of 76 isolates maximum sensitivity was shown with Vancomycin and Linezolid i.c 100% followed by Minocycline (96%), Teicoplanin (88%), Tetracycline (83%), Doxicycline (80%), Chloramphenicol (77%), Gentamicin (76%), Clindamycin (59%), Erythromycin (21%) and less sensitive were Ciprofloxacin (20%), Levofloxacin (20%) & Penicilin-G (08%). Resistant isolates was higher among Penicilin-G (92%) followed by Ciprofloxacin (80%), Levofloxacin (80%), Erythromycin (79%), Gentamicin (24%), Clindamycin (41%), Chloramphenicol (23%) and less Resistant was shown to Teicoplanin (12%), Tetracycline (17%), Doxicycline (20%) and Minocycline (04%). Conclusion: Staphylococcus aureus continues to be a health problem for both community-acquired and hospital-associated infections. Finally concluded that continuous monitoring of antibiotic susceptibility pattern of S. aureus and use of a right and proper antimicrobial drug will be helpful for minimizing the resistance to beta lactams and other group of antibiotics.
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