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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 12, Issue:9, September, 2023

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2023.12(9): 67-79
DOI: https://doi.org/10.20546/ijcmas.2023.1209.007


Sickle Cell Anaemia: Case Presentations from the Indian Tribal Population and Discussion on the Clinicopathologic Aspects
Ruchi Kumari1 and Manisha Shukla2*
1School of Biotechnology, Kalinga Institute of Industrial Technology University,Bhubaneswar, Odisha, India
2Department of Biotechnology, Pandit S.N. Shukla University, Shahdol, Madhya Pradesh, India
*Corresponding author
Abstract:

Sickle cell anaemia (SCA) is one of the gravest inherited disorders which cannot be cured and greatly impacts a person’s quality of life. It is a red blood cell-related disorder which happens due to a mutation in haemoglobin gene. This paper details the pathophysiology and clinical presentation of three homozygous sickle cell anaemia patients from three different age groups from the tribal population of Shahdol, Madhya Pradesh and throws light on their complaints, prognosis, hospital visits, tests, recommendations, and the likely course of medical and surgical management. The degree of severity varies from person to person based on access to early screening and diagnosis and knowledge of the clinical interventions available. The paper discusses all the 3 cases comprehensively and connects the dots between the common complaints. Hepatopathy and splenopathy in the afflicted patients are a common observation in SCA patients and a threshold point where the physical ailment becomes inevitable. A high neutrophil to lymphocyte ratio (NLR) is another observation and it can be investigated more in depth to aid in SCA identification. The paper also emphasises on newborn screening in the highly affected tribal populations to save them from the later complications and on educating them about SCA.


Keywords: Sickle cell anaemia (SCA), Haemoglobin (Hb), Tribal population, Hepatomegaly

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How to cite this article:

Ruchi Kumari and Manisha Shukla. 2023. Sickle Cell Anaemia: Case Presentations from the Indian Tribal Population and Discussion on the Clinicopathologic Aspects.Int.J.Curr.Microbiol.App.Sci. 12(9): 67-79. doi: https://doi.org/10.20546/ijcmas.2023.1209.007
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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