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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 12, Issue:9, September, 2023

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2023.12(9): 1-14
DOI: https://doi.org/10.20546/ijcmas.2023.1209.001


Physiopathology of Liver cirrhosis: A Growing Public Health Concern in Sub-Saharan Africa
Nouhoun Nignan1Lassina Traoré1, Marie Simone Traoré2, Bolni Marius Nagalo3, 4,Abdoul Karim Ouattara5, Rogomenoma Alice Ouédraogo6, Teega-Wendé Clarisse Ouédraogo1Pingdwende Abel Sorgho7Tégwindé Rebeca Compaoré8, Sidnooma Véronique Zongo1,Prosper Bado7Florencia Wendkuuni Djigma1, 7*, Albert Théophane Yonliand Jacques Simporé1
1Université Joseph KI-ZERBO, Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), P.O. Box 7021, Ouagadougou 03, Burkina Faso;
2Ecole Normale Supérieure, P.O Box1757, Koudougou, Burkina Faso
3Department of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA
4The Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA
5Université Nazi Boni, P.O Box 1091 Bobo-Dioulasso 03, Burkina Faso
6Université Norbert ZONGO, P.O Box 376, Koudougou;
7Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), P.O. Box 364,Ouagadougou 01, Burkina Faso;
8Centre National de la Recherche Scientifique et Technologique, Institut de Recherche en Science de la Sante, 03 BP 7047 Ouagadougou
*Corresponding author
Abstract:

This study aims to comprehensively review the literature pertaining to the management of liver diseases, especially cirrhosis in sub-Saharan Africa. Specifically, it involves a meticulous synthesis and analysis of data concerning the physiopathology of liver cirrhosis, an assessment of the clinical manifestations associated with the condition, and an exploration of the presence and efficacy of therapeutic approaches utilizing conventional medicinal plants. The present study investigation included studies published between 2017 and 2022, focusing on the physiopathology of liver cirrhosis, primarily attributed to HBV and HCV etiologies. Additionally, we examine clinical manifestations and investigate the therapeutic potential of plant-derived remedies for liver cirrhosis. Inclusion criteria encompassed clinical studies, clinical trial protocols, and evaluation studies, while studies concurrently involving cirrhosis, HIV, and Covid-19, as well as reviews, correspondences, books, and case reports were excluded. A total of twenty-one articles were selected for this review. Physiopathology of liver cirrhosis: the collective evidence underscores the role of chronic hepatitis B virus (HBV) infection as a risk factor for liver cirrhosis. Age distribution within the cirrhotic population ranged from 18 to 71 years, with a predominance of male patients (ranging from 58.89% to 91%). Disease progression revealed distinct phases encompassing fibrosis, compensated cirrhosis, and decompensated cirrhosis culminating in the definitive establishment of liver cirrhosis. Ultimately, liver cirrhosis was associated to mortality due to hepatocellular carcinoma (HCC). Clinical manifestations of liver cirrhosis: analytical parameters encompassed serum, plasma, liver, total blood, and spleen evaluations. Serological tests involved liver biochemical markers (ALT, AST, TBIL, ALB, AFP, Bilirubin, PT, GGT), Antigens and/or Antibodies (HBsAg, HBeAg, Anti-HBs, anti-HBe), blood cell and lymphoid cell assessments (blood count, PLT), T lymphocytes, NK-Cells, Neutrophils, Leukocytes, Erythrocytes), HBV DNA, cytokines (IFN, IL, TNF, TGF), and creatinine levels. The patient demographics encompassed those with Hepatitis B-induced cirrhosis, patients with chronic HBV infection, those with concurrent HBV infection and liver fibrosis/cirrhosis, co-positive HBsAg/Anti-HBs individuals, single-positive HBsAg patients, individuals with prolonged positive HBsAg status, patients with compensated HBV-associated cirrhosis, individuals with hepatotoxicity, and patients with chronic liver disease. Existence and utility of a therapeutic management based on traditional drugs: several studies highlight the presence of treatment modalities utilizing traditional recipes. Notable among these are "erzhu jiedu," Echinacea-based formulations, and Curcumin-based regimens. This study compiled a comprehensive dataset comprising liver cirrhosis, encompassing its physiopathology, clinical manifestations, and the feasibility of therapeutic interventions grounded in traditional medicine. These findings provide importants insights for future research endeavors, potentially endorsing the adoption of traditional medicinal recipes while concurrently assessing the biological parameters elucidated in this study.


Keywords: Physiopathology, liver cirrhosis, clinical manifestations, therapeutic management, traditional drugs

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How to cite this article:

Nouhoun Nignan, Lassina Traoré, Marie Simone Traoré, Bolni Marius Nagalo, Abdoul Karim Ouattara, Rogomenoma Alice Ouédraogo, Teega-Wendé Clarisse Ouédraogo, Pingdwende Abel Sorgho, Tégwindé Rebeca Compaoré, Sidnooma Véronique Zongo, Prosper Bado, Florencia Wendkuuni Djigma, Albert ThéophaneYonli and Jacques Simporé. 2023. Physiopathology of Liver cirrhosis: A Growing Public Health Concern in Sub-Saharan Africa.Int.J.Curr.Microbiol.App.Sci. 12(9): 1-14. doi: https://doi.org/10.20546/ijcmas.2023.1209.001
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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