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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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Original Research Articles                      Volume : 12, Issue:4, April, 2023

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2023.12(4): 135-141
DOI: https://doi.org/10.20546/ijcmas.2023.1204.015


To Study Activity of Fosfomycin Against Extended Spectrum Beta- Lactamases in Uropathogens in a Tertiary Level Maternity Hospital of Western Rajasthan
Vishakha Ashopa, Ekta Gupta, Eshank Gupta, Anjali Beelwal and Prabhu Prakash*
Department of Microbiology, Dr S.N.M.C., Jodhpur, India
*Corresponding author
Abstract:

Urinary tract infections are the most important healthcare complications experienced in medicine and urology. Unfortunately, besides B-lactams, the Extended spectrum beta lactam producing Gram negative uropthogens causing UTI have become associated with resistance to other antibiotics such as aminoglycosides, fluoroquinolones etc. The use of old antibiotic such as Fosfomycin been introduced again in the field of therapeutic. The present study was conducted prospectively in the Department of Microbiology, Jodhpur, Rajasthan. Over a period of 6 months. Mid-stream morning urine samples were collected aseptically. Semi quantitative culture was done on UTI HICROME Agar. Results: In present study time 2000 (40.97%) urine sample were received, out of which 1511 (75.55%) were culture positive, 300 (15%) were sterile and 189 (9.45%) were insignificant bacterial count, Gram negative bacilli were 1100 (72.79%), Gram positive cocci were 411 (27.200%). Among GNB isolates Escherichia coli 501 (45.54%) was the most common isolate followed by Klebseilla spp.189 (17.18%), Citrobacter spp. were 130(11.81%), Pseudomonas spp.120 (10.90%), Aceinatobacter spp.110 (10%) and Proteus spp. were 50 (4.54%). Age-wise distribution 20-29 years (60.36%) group was the most common. Fosfomycin was the most sensitive antibiotic was reported. The culture and Antibiotic sensitivity testing (AST) of uropathogens should be done. Fosfomycin found to be suggesting that it could be used as empiric monotherapy for uncomplicated UTIs.


Keywords: UTI, GNB, GPC, AST, ESBL, Fosfomycin, fluoroquinolones, cephalosporins

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How to cite this article:

Vishakha Ashopa, Ekta Gupta, Eshank Gupta, Anjali Beelwal and Prabhu Prakash. 2023. To Study Activity of Fosfomycin Against Extended Spectrum Beta- Lactamases in Uropathogens in a Tertiary Level Maternity Hospital of Western Rajasthan.Int.J.Curr.Microbiol.App.Sci. 12(4): 135-141. doi: https://doi.org/10.20546/ijcmas.2023.1204.015
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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