The current study was carried out to identify and to evaluate some risk factors, clinical picture, pathological changes and treatment in donkey naturally infected by ringworm. A questionnaire was designed to 100 owners of suspected donkey with ringworm and included age, sex, breed, season, source of drug, drug use, lesion, housing, bedding, disposal of manure and animal purpose. A total of 36 donkeys naturally infected by the disease were examined visually (lesion shape, size, distribution, configuration and depth lesion). Health parameters were examined (respiratory and pulse rates ad rectal temperature). Blood for serum was taken to determine total protein, albumin, creatinine, aspartate aminotransferase, alanine aminotransferase, zinc and copper. Skin scraping was used for mycological examination and skin biopsy was taken for histopathological changes. The treatment was applied using clotrimazole cream (1%) and Azadireachta indica examination. The results of the respondents revealed that old animals were infected by the disease (43 owners), and males (60 owners) were infected more than females (40 owners). Most of the lesions appeared in winter (37 owners) and treated by antifungal (41 owners). The majority of these animals were tethered (48 owners) and their bedding was sand (63 owners). Health parameters of infected donkeys showed no statistically significant differences (P<0.05). But blood biochemical parameters revealed statistically significant difference at P-value 0.05 in infected animals. Mycological examination identified two genera and these were Trichophyton spp and Microsporm spp. histopathological changes were production of keratinized-epithelial cells, presence of inflammatory cells and mycelia around the hair follicles and desquamation of epithelial cells. All animals were treated by clotrimazole (1%) and 32 (88.8%) were recovered and also 27 (75%) were response to the herbal therapy. In conclusion, ringworm is spreading in donkeys in the study area and these animals are important for human purposes. The diagnosis of the disease can clinically, mycologically, histopathollogically and estimation of the blood chemistry. The herbal therapy can be developed as the drug for treatment of the disease.

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