National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Bronchial asthma is a chronic respiratory disorder influenced by both genetics and environmental factors. The pathology of asthma is characterized by an increased influx of TH2 cells, eosinophils, increased circulating immunoglobulin E (IgE) and mucus hypersecretion in the airways. Respiratory bacterial infections in early childhood is closely associated with the development of bronchial asthma, andis also the greatest contributing factor to asthma exacerbation in both children and adults. Typical and atypical bacterial species that have been linked with asthma exacerbations include Haemophilus influenza, Streptococcus pneumoniae, Mycoplasma pneumonia and Chlamydia pneumonia. Moreover, microbiome compositions and particular imbalances in respiratory flora are also responsible for asthma exacerbations early in life and play a significant role as a determinant of respiratory health and potential asthma development. This reviews highlights on the role of respiratory microbiome and bacterial pathogens in triggering the immune response resulting in asthmatic attacks and exacerbations.
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