International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 10, Issue:6, June, 2021

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(6): 729-739

Antimicrobial Metabolites from Halophilic Actinomycete Nocardiopsis sp. Al-H10-1 (KF384482) Isolated from Alang, Gulf of Khambhat, India
Nisha Trivedi1 and Jignasha Thumar2*
1Department of Microbiology, School of Science, RK University,  Rajkot - 360020, Gujarat, India 2Department of Microbiology, Government Science College, Gandhinagar-382015, Gujarat, India
*Corresponding author

The overuse of antibiotics has resulted in the development of drug resistant, a major problem in disease curing processes i.e. development of drug resistance. The World Health Organization (WHO) released its first list of the most concerning pathogens for human health in 2017 which suggested that there are total 12 bacterial families which have developed multiple drug resistance and for which novel antibiotics are required immediately (WHO 2017). There is a requirement to explore some novel compounds to overcome this issue. Thus our study aimed at exploration of marine actinomycetes as a valuable resource for novel products with antimicrobial properties. The halophilic actinomycete Nocardiopsis sp. Al-H10-1 (KF384482) was isolated from saline water (20 m away from shore) of Alang coast (Gulf of Khambhat), Bhavnagar, Gujarat, India. The isolate Al-H10-1 was identified as Nocardiopsis sp. through rigorous morphological and cultural characteristics; the species was confirmed through 16s rRNA phylogenetic analysis. The antimicrobial potential of Nocardiopsis sp. Al-H10-1 was assessed against a range of Gram-positive and Gram-negative bacteria as well as three fungi, there it demonstrated antimicrobial activity against four Gram negative bacteria and one Gram positive bacteria. The isolate didn’t show any antifungal activity. The results of optimization showed that the highest antimicrobial compound production was obtained in the presence of 0.5 % starch, 10% NaCl and pH 9.

Keywords: Marine actinomycetes; halophilic; 16S rRNA gene sequencing; antimicrobial activity; spot inoculation method; optimization; OVAT method

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How to cite this article:

Nisha Trivedi and Jignasha Thumar. 2021. Antimicrobial Metabolites from Halophilic Actinomycete Nocardiopsis sp. Al-H10-1 (KF384482) Isolated from Alang, Gulf of Khambhat, India.Int.J.Curr.Microbiol.App.Sci. 10(6): 729-739. doi:
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