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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 373-381
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.044


 Basic Core Promotor Mutations of HBV as Early Biomarkers for  Hepatocellular Carcinoma in Egyptian Patients
Nermeen Tayseer Aly Fouad1*, Dina ElShennawy1, Rania A. Abo-Shady1, Hossam M. Fahmy1, Hala Ghareeb1, Rania H ElKabarity1, Marcel W. Keddeas2 and Amal T. Abdel Moez3
1Clinical Pathology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Internal Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Tropical Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
*Corresponding author
Abstract:

Hepatitis B virus (HBV) infection is a major health problem worldwide. Several mutations at the BCP region of HBV have been recently associated with an increased risk of HCC, and thus can serve as useful biomarkers for predicting the clinical outcome of chronic HBV patients. Genome sequencing of the BCP region of the HBV, in 80 chronically HBV infected patients (40 of whom had developed HCC), was performed in this study to identify the presence of mutations and to clarify whether any of these mutations could be considered as a biomarker for early detection of HCC in Egyptian patients. We found that T1753V and A1762T mutations were found in 22.5% and 20% of HCC group with significant difference versus non HCC group, while double mutations A1762T, G1764A were only found in a small percentage (5%) of HCC group. It could be concluded that the T1753V and the A1762T mutations, but not A1762T, G1764A, are strongly associated with development of HCC in chronic HBV Egyptian patients and could be used as valuable markers for early detection of HCC.


Keywords: HBV, T1753V, A1762T, G1764A,HCC,BCP.
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How to cite this article:

Nermeen Tayseer Aly Fouad, Dina ElShennawy, Rania A. Abo-Shady, Hossam M. Fahmy, Hala Ghareeb, Rania H. ElKabarity, Marcel W. Keddeas and Amal T. Abdel Moez. 2016. Basic Core Promotor Mutations of HBV as Early Biomarkers for  Hepatocellular Carcinoma in Egyptian Patients.Int.J.Curr.Microbiol.App.Sci. 5(3): 373-381. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.044