National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The effect of quercetin pre-treatment (10 and 20 mg.Kg-1), 30 minutes before the single oral administration of meloxicam at the dose rate of 1.5mg.Kg-1,was studied on the pharmacokinetics of meloxicam. Eighteen adult male rabbits were divided into 3 groups of 6 animals each. Group 1 received meloxicam alone @ 1.5 mg.Kg-1 b. wt. orally, group 2 received meloxicam @ 1.5 mg.Kg-1 b. wt. orally 30 min post-treatment with quercetin @ 10 mg.Kg-1 b. wt. orally, while group 3 received meloxicam @ 1.5 mg.Kg-1 b. wt. orally 30 min post-treatment with quercetin @ 20 mg.Kg-1 b. wt. orally. Plasma concentrations of meloxicam were determined at specified time intervals by using high performance liquid chromatography(HPLC). The plasma concentration versus time data of meloxicam was adequately described by a non compartment model. The area under plasma concentration – time curve(AUC0-t) (p<0.01), area under first moment curve (AUMC0-t) (p<0.05), volume of distribution at steady state(Vdss) (p<0.05) and peak plasma concentration(ClB) (p<0.01) in quercetin 20 mg.Kg-1pre-treatment group were significantly different from the corresponding values of control group. Quercetin pre-treatment @ 10 mg. Kg-1 had no significant effect on the pharmacokinetic profile of meloxicm in rabbits.
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