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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(5): 624-630
DOI: https://doi.org/10.20546/ijcmas.2021.1005.070


Studies on the Pharmacokinetic Interaction between Meloxicam and Quercetin, A CYP2C9 and CYP3A4 Inhibiting Flavonoid, in Rabbits
K. Jayakanth1, K. Sireesha2*, P. Ravikumar3 and K. Adilaxmamma4
1Department of Veterinary Science, Krishna District, India 2Department of Livestock production and Management, College of Veterinary Science, Sri Venkateswara Veterinary University, Garividi, India 3Department of VPT, NTR College of Veterinary Science, Gannavaram, India 4Department of Veterinary Science, Tirupathi 516 360, India
*Corresponding author
Abstract:

The effect of quercetin pre-treatment (10 and 20 mg.Kg-1), 30 minutes before the single oral administration of meloxicam at the dose rate of 1.5mg.Kg-1,was studied on the pharmacokinetics of meloxicam. Eighteen adult male rabbits were divided into 3 groups of 6 animals each. Group 1 received meloxicam alone @ 1.5 mg.Kg-1 b. wt. orally, group 2 received meloxicam @ 1.5 mg.Kg-1 b. wt. orally 30 min post-treatment with quercetin @ 10 mg.Kg-1 b. wt. orally, while group 3 received meloxicam @ 1.5 mg.Kg-1 b. wt. orally 30 min post-treatment with quercetin @ 20 mg.Kg-1 b. wt. orally. Plasma concentrations of meloxicam were determined at specified time intervals by using high performance liquid chromatography(HPLC). The plasma concentration versus time data of meloxicam was adequately described by a non compartment model. The area under plasma concentration – time curve(AUC0-t) (p<0.01), area under first moment curve (AUMC0-t) (p<0.05), volume of distribution at steady state(Vdss) (p<0.05) and peak plasma concentration(ClB) (p<0.01) in quercetin 20 mg.Kg-1pre-treatment group were significantly different from the corresponding values of control group. Quercetin pre-treatment @ 10 mg. Kg-1 had no significant effect on the pharmacokinetic profile of meloxicm in rabbits.


Keywords: Meloxicam, Pharmacokinetics, Quercetin, Rabbits
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How to cite this article:

Jayakanth, K., K. Sireesha, P. Ravikumar and Adilaxmamma, K. 2021. Studies on the Pharmacokinetic Interaction Between Meloxicam and Quercetin, A CYP2C9 and CYP3A4 Inhibiting Flavonoid, in Rabbits.Int.J.Curr.Microbiol.App.Sci. 10(5): 624-630. doi: https://doi.org/10.20546/ijcmas.2021.1005.070