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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(5): 195-202
DOI: https://doi.org/10.20546/ijcmas.2021.1005.026


Haemato-Biochemical Changes associated with Intramuscular Administration of Amikacin
Namrata Upadhyay1, Nitesh Kumar1, Arpita Shrivastav1, Swatantra Singh1, Neeraj ShrivastavaManoj Kumar Ahirwar3, Sumat Kumar Shakyaand Rajeev Ranjan1*
1Department of Veterinary Pharmacology and Toxicology,
2Department of Veterinary Microbiology,
3Department of Veterinary Physiology and Biochemistry,
4Department Livestock Production and Management, College of Veterinary Science and A.H., Rewa, (NDVSU, Jabalpur), Madhya Pradesh, India
*Corresponding author
Abstract:

Aminoglycosides are antibiotics, often used in veterinary and human medicine for treatment of various infections caused by gram negative and some gram positive micro-organisms. Due to its inherent property of being refractory to most aminoglycoside modifying enzymes. Amikacin has been successfully used to treat the life threatening antimicrobial resistant infections. These antibiotics is their relatively low therapeutic index. The use at therapeutic doses may lead to adverse changes in haemato-biochemical parameters, especially with those connected with kidney and liver function. The aim of the present study was to determine the changes in some haemato-biochemical parameters on 1st, 3rd, 5th and 7th days after intramuscular administration with amikacin at therapeutic dose @10 mg/kg bwt for 5days in four healthy non lactating female goats. The results of present studies indicated that in healthy goats, at therapeutic doses of amikacin caused significant (p < 0.05) rise in serum BUN and creatinine level, but no significant (p < 0.05) changed observed in blood Hb, PCV, TLC, lymphocytes, monocytes, eosinophils, basophil and neutrophils and the serum albumin, globulin, total protein, bilirubin, cholesterol and triglyceride level during the experiment. Amikacin also caused significant (p < 0.05) rise in serum enzyme ALT, AST and ALP level. On the whole, the results of these studies demonstrate that amikacin have potential for altering biochemical and haematological values in female goats after using amikacin at therapeutic doses.


Keywords: Amikacin, Goats, Intramuscular,Haemato-biochemical, Dosage
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How to cite this article:

Namrata Upadhyay, Nitesh Kumar, Arpita Shrivastav, Swatantra Singh, Neeraj Shrivastava Manoj Kumar Ahirwar, Sumat Kumar Shakya and Rajeev Ranjan. 2021. Haemato-Biochemical Changes associated with Intramuscular Administration of Amikacin.Int.J.Curr.Microbiol.App.Sci. 10(5): 195-202. doi: https://doi.org/10.20546/ijcmas.2021.1005.026