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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(4): 617-631
DOI: https://doi.org/10.20546/ijcmas.2021.1004.062


A Study on Oxidative Stress Induced Cardiotoxicity by Cisplatin and Protective Evaluation by Tinospora cordifolia and vitamin C
Nisaath Begum1*, P. Shiva Kumar1, A. Gopala Reddy2, B. Ramya3,Kalyani4, B. Anil Kumar1 and M. Usha Rani1
1Department of Veterinary Pharmacology and toxicology,
2Department of Veterinary Pharmacology and toxicology and Registrar of PVNRTVU,
3Department of Veterinary Clinical Complex,
4Department of Veterinary Biotechnology, College of Veterinary Science,
Rajendranagar, Hyderabad – 500 030, Telangana, India
*Corresponding author
Abstract:

The ameliorative potential of Tinospora cordifolia (TC) and vitamin C (Vit. C) was studied against oxidative stress induced cardiotoxicity by cisplatin. 36 male Wistar rats were divided into 6 groups(n = 6). Group 1 was maintained as Normal control. Cisplatin (7.5 mg/kg B.W) was administered intraperitoneally to the groups 2, 5 and 6 on day 1. Groups 3 and 4 were administered for 14 days (p/o) with aqueous leaf extract of TC (400 mg/kg B.W) and vitamin C (100 mg/kg B.W), respectively from day 1. Group 5 and 6 received aqueous leaf extract of TC (400 mg/kg B.W)and vitamin C(100 mg/kg B.W), respectively for 14 days orally starting from the 1st day of cisplatin injection. Body weights, antioxidant parameters and cytokine profile were assessed. The present study revealed a significant (P < 0.05) increase in TBARS, protein carbonyls, TNF-alpha and IL-10, while significant (P < 0.05) decrease in GSH in group 2 compared to group 1. The groups 5 and 6 showed significant improvement in all the parameters in comparison to group 2.In conclusion beneficial effects of TC and vitamin C could be attributed to their antioxidant and immunomodulatory actions.


Keywords: Cisplatin, Tinospora cordifolia, Vitamin C, Oxidative stress, Cardiotoxicity
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How to cite this article:

Nisaath Begum, P. Shiva Kumar, A. Gopala Reddy, B. Ramya, P. Kalyani, B. Anil Kumar and Usha Rani, M. 2021. A Study on Oxidative Stress Induced Cardiotoxicity by Cisplatin and Protective Evaluation by Tinospora cordifolia and vitamin C.Int.J.Curr.Microbiol.App.Sci. 10(4): 617-631. doi: https://doi.org/10.20546/ijcmas.2021.1004.062