National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Plants are the main source of drugs nowadays. They provide a high benefit to risk ratio. Naringenin is a plant flavonoid obtained from citrus fruits. It exhibits plethora of effects against a number of diseases. Agar dilution method was used to evaluate minimum inhibitory concentration (MIC) naringenin and three β-lactam drugs amoxicillin, oxacillin and cloxacillin. Checkerboard method was used to determine the fractional inhibitory concentration (FIC) of the drugs in combination with naringenin. Naringenin was reported to have an MIC value of 125μg/ml. The flavonoid showed synergistic effect with both oxacillin (7 strains) and cloxacillin (8 strains) whereas it showed indifference on combination with amoxicillin. Thus from all the results it can be concluded that Naringenin inhibited growth of MRSA and enhanced the anti-microbial effect of the conventional drugs included in the study.
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