International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 10, Issue:3, March, 2021

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(3): 1799-1809

Antibacterial Potential of Citrus Flavonoid, Naringenin with β-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus (MRSA)
Ameesha Tomar1, 2, Shobha Broor1, Swati Kaushik2, Tanisha Bharara1 and D. S. Arya2*
1Department of Microbiology, Faculty of Medicine and Health Sciences, SGT University, Gurgaon, Haryana, India
2Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
*Corresponding author

Plants are the main source of drugs nowadays. They provide a high benefit to risk ratio.  Naringenin is a plant flavonoid obtained from citrus fruits. It exhibits plethora of effects against a number of diseases. Agar dilution method was used to evaluate minimum inhibitory concentration (MIC) naringenin and three β-lactam drugs amoxicillin, oxacillin and cloxacillin. Checkerboard method was used to determine the fractional inhibitory concentration (FIC) of the drugs in combination with naringenin. Naringenin was reported to have an MIC value of 125μg/ml. The flavonoid showed synergistic effect with both oxacillin (7 strains) and cloxacillin (8 strains) whereas it showed indifference on combination with amoxicillin. Thus from all the results it can be concluded that Naringenin inhibited growth of MRSA and enhanced the anti-microbial effect of the conventional drugs included in the study.

Keywords: MRSA, β-Lactam, Antibiotics, Naringenin, Linezolid

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How to cite this article:

Ameesha Tomar, Shobha Broor, Swati Kaushik, Tanisha Bharara and Arya, D. S. 2021. Antibacterial Potential of Citrus Flavonoid, Naringenin with β-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus (MRSA).Int.J.Curr.Microbiol.App.Sci. 10(3): 1799-1809. doi:
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