National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Biofilm is an aggregate of microorganisms forming multicellular communities where cells are stuck cooperatively by a produced by oneself Matrix Extracellularis. Biofilm formation by microorganisms is a ubiquitous, omnipresent & active mechanism. This vigorous ability of microbes to form biofilms proves to be a key technique for resisting and surviving in adverse climatic conditions as well as antibacterial compounds. Numerous features of biofilms contributed by component of extracellular matrix and microbial community allows in tolerating adverse conditions. Microbes in a biofilm have a remarkable property of resistance against antimicrobials, in contrast with free-swimming planktonic cells. Antimicrobial tolerance is the tendency of microbes like fungi, bacteria, or protozoans to evolve amid sensitivity to antimicrobial compounds engineered to prevent their proliferation. The development of resistance by microorganisms to antimicrobial drugs implies that these drugs are no longer effective in treating contagious illnesses which continues pioneering consequence of death rates broadly. It is believed that Coevolving bacteria with contagious microbes in biofilms have been establishing defense toward bioactive compounds from the atmosphere and to withstand their natural antibiotics and protection substances. This tolerance in infectious microorganisms Protects from chemotherapeutic interference and cause biofilm-based infections that are hard to heal. In this article, we briefly look into the characteristics of biofilms, the process of their development, and antibiotics tolerance of Biofilm-forming microbes. A vast variety of molecular pathways lead to biofilm-based antibiotic resistance have been proposed which include, effect of environmental stresses, slow growth response, restriction to antimicrobial penetration in biofilms, quorum sensing, etc. Any of these processes when acts alone only partially responsible for the increased antimicrobial resistance in biofilms. However, working together, such defenses surely enable biofilm cells longevity even against the most aggressive antimicrobial agents.
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