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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2016: 92.3
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): 2164-2178
DOI: https://doi.org/10.20546/ijcmas.2017.604.254


Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice
Luna Dutta Baruah1*, Rohini Devi3, Dhruba Jyoti Nath2, Vijaya Nalwade3, Asha Arya3 and Sudhir Rajurkar4
1Department of Food Science and Nutrition, Assam Agricultural University,Jorhat-785013, Assam, India
2Department of Soil Science, Assam Agricultural University, Jorhat-785013, Assam, India
3Department of Food and Nutrition, Vasantrao Naik Marathwada Agricultural University, Parbhani-431402, Maharashtra, India
4Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Vasantrao Naik Marathwada Agricultural University, Parbhani-431402, Maharashtra, India
*Corresponding author
Abstract:

The current study sought to investigate the anti-fatigue efficacy of poly herbal granule (PHG) formulations of the extracts of Asparagus racemosus, Chlorophytum borivilianum, Tinospora cordifolia, Tribulus terrestris and Withania somnifera enriched with general tonic and health promoting properties based on Aloe vera gel and soyabean whey in Swiss mice. The nutrient compositions of the selected PHG exhibited that the carbohydrates were the major constituents in both AVII and SBWII, followed by protein and total ash. Fat contents were 0.96 and 1.18 g100g-1 in AVII and SBWII, respectively. The energy levels of AVII and SBWII were 378 and 377 kcal100g-1, correspondingly. Higher contents of Ca (70.20 mg100g-1), Mg (85.27mg100g-1) and P (61.55 mg100g-1) were observed in SBWII. The trace elements revealed that, Zn and Fe content were 1.84 and 8.63mg100g-1in AVII and 1.85 and 7.85mg100g-1in SBWII, respectively. The retention and stability of Vitamin C, total sugar, reducing sugar and non-reducing sugar for 270 days illustrated the storage life of the product in ambient condition. The body weight of mice, swimming time and corresponding biochemical parameters including haemoglobin, serum protein and blood glucose level were measured by standard method. The oral administration with PHG supplement for 30 days markedly increased the body weight (11.40-11.80%), haemoglobin (11.82-12.46%), serum protein (3.77-6.02%) of the mice. Following forced swimming test (FST), prolonged exhaustive exercise time of 231.02 (AVII), 237.50 (SBWII) minutes were recorded for PHG supplemented groups which were 36.23 (AVII) and 37.97 (SBWII) per cent longer than that of the control group. The minute increase of blood glucose levels (4.51-4.37%) in PHG supplemented Swiss mice after FST as compared to tremendous increase in blood glucose level (40.07%) in the control group illustrated the anti-fatigue activity of PHG.


Keywords: Polyherbal granules, Haemoglobin, Forced swimming tests, Blood glucose.
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How to cite this article:

Luna Dutta Baruah, Rohini Devi, Dhruba Jyoti Nath, Vijaya Nalwade, Asha Arya and Sudhir Rajurkar. 2017. Development of Poly Herbal Granules and Its Anti- Fatigue Efficacy in Swiss Mice.Int.J.Curr.Microbiol.App.Sci. 6(4): 2164-2178. doi: https://doi.org/10.20546/ijcmas.2017.604.254